//genesis
//SynParamsCtx.g
str AMPAname = "AMPA"
float EkAMPA = 0.0
float AMPAtau1 = 1.1e3 //wolf with qfact of 2 taken into account (t1 and t2)
//float AMPAtau2 = 5.75e3 //these tau are quite slow compared to hippocampal values
//float AMPAgmax = 0.51e9 // 45 mV PSP, AP calcium trivial compared to PSP
//float AMPAtau1=0.2e3
float AMPAtau2=2.0e3 // double hippo values; faster than GABA
float AMPAgmax=0.9e9//0.125e9 //0.15 0.19 25 mV PSP, AP calcium higher than PSP calcium 0.342e9
float AMPACaper = 0.001//0.00 //0.001 //percent AMPA conductance that is carried by calcium. value from wolf //more like 2/1 for thalamus so should be 0.47e9 for thalamostriatal syanpnse if NMDA is 0.94e9 Rebekah Evans 6/25/10
float AMPAdes = 0.39 //1.7 //desensitization factor, (depr_per_spike field of facsynchan)
float AMPAdestau = 0.8 // 0.54 // desensitization tau (how fast des recovers)
str GABAname = "GABA"
float GABAtau1 = 1.0e3//0.25e3 // 0.25e3From Galarreta and Hestrin 1997
float GABAtau2 = 14.4e3//80.75e3 //(3.75e3 used in Wolfs model; 80.75e3 used by Asia; from NPY_Neurogliaform with slow GABAA current)
float EkGABA = 0.060 //calculated Kerr and Plenz 2004 Erev for Cl, is 60 mV 5/2/12 RCE
float GABAgmax = 1200e12//5000e12 used by Asia //was 750, Sri uses 900 //Modified Koos 2004 (Wolf uses 435e12)
/*Notes on GABA: gmax= 600 pS would not be unreasonable for LTSI based on Straub...Sabatini (2016), might be larger due to being distally located;
gmax = 12001800 pS for NPYNGF based on IbanezSandoval...Tepper (2011); similar for FSI (Straub et al 2016)
LTSI,FSI: tau rise: ~.52.0 ms (mean ~1.0); tau decay ~ 1030 ms (mean~14.4) (based on Straub, IbanezSandoval). LTSI appears slower in somatic voltage clamp, likely due to distally located synapses
NPYNGF: tau rise: 10 ms (range 319), tau decay: 83 (range 29127) (From IbanezSandoval et al. Consistent with other GABA_A_slow currents in other NGF interneurons) */
float GABAdelay = 0.02
int ghk_yesno=1 //0 no ghk objects for NMDA, 1 add ghk to NMDA
//ghk reduction factor and hoook ups to calcium shells are in Addsynapticchannels.g
// parameters for NMDA subunits
// cortex
str subunit = "ctx"
float EkNMDA = 0
float Kmg = 18 //18 new //3.57 old overwrites 1/eta in nmda_channel.g
if ({subunit}=="NR2A")
float NMDAtau2 = {(50e3)/2}
elif ({subunit}=="NR2B")
float NMDAtau2 = (300e3)/2
elif ({subunit}=="ctx")
float NMDAtau2 = (112.5e3)/2 // ctx avg for .25 NR2B and .75 NR2A.
else
echo "no other NMDA subunits defined in SynParamsCtx.g"
end
float N2Aratio=1.0 //NMDA to AMPA ratio of 1:1 is in middle of measured range for striatum
float NMDAgmax = {AMPAgmax}*{N2Aratio} //0.94e9 NR2A and B from (Moyner et al., 1994 figure 7)
//0.47e9 using 2.75:1 NMDA:AMPA (Ding 2008), which is extreme.
float NMDAperCa = 0.1 // percent calcium influx Note: Divided by 2 in AddSynapticChannel for GHK case because of the enhanced driving potential: ohmic to GHK, reversal potentail from 0 to huge value
float NMDAfactGHK = 35e9//35e9 //adjustment factor for GHK to calcium shell/pool
//This is necessary because GHK reads in Gk from block and interprets it as permeability. this results in ridiculous current, restored to normal by factor of ~e8
float NMDAdes = 0 //1 //desensitization factor, (depr_per_spike field of facsynchan)
float NMDAdestau = 0 //200e3 // desensitixation t (how fast des recovers)
str NMDAname = {subunit}
int nmdacdiyesno = 1 // 1 or 0, whether to implement nmda_cdi
//for saving info on distal or proximal dendrites or massed and spaced. formula typeof dend, # of spines.
//parameters for NMDA calcium interactions
int NMDABufferMode = 0 // 1, connect both NMDA and AMPA calcium to Calcium_pool
// 0, connect only NMDA currents to calcium_pool
str bufferNMDA="Ca_pool_nmda"
if ({calciumtype}==0)
str NMDApool= {CalciumName}@"1"
else
str NMDApool={bufferNMDA}
end
