Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)

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Accession:245411
We use a computational model of a striatal spiny projection neuron to investigate dendritic spine calcium dynamics in response to spatiotemporal patterns of synaptic inputs. We show that spine calcium elevation is stimulus-specific, with supralinear calcium elevation in cooperatively stimulated spines. Intermediate calcium elevation occurs in neighboring non-stimulated dendritic spines, predicting heterosynaptic effects. Inhibitory synaptic inputs enhance the difference between peak calcium in stimulated spines, and peak calcium in non-stimulated spines, thereby enhancing stimulus specificity.
Reference:
1 . Dorman DB, Jedrzejewska-Szmek J, Blackwell KT (2018) Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model. Elife, Kennedy, Mary B, ed. [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): Ca pump; Kir; I A; I A, slow; I CAN; I K,Ca; I Krp; I Na,t; I L high threshold; I R; I T low threshold; IK Bkca; IK Skca; Na/Ca exchanger;
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s): Cav3.2 CACNA1H; Cav3.3 CACNA1I; Cav1.2 CACNA1C; Cav1.3 CACNA1D; Cav2.2 CACNA1B; Kv4.2 KCND2; Kir2.1 KCNJ2; Kv2.1 KCNB1;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Calcium dynamics; Detailed Neuronal Models; Synaptic Integration; Synaptic Plasticity;
Implementer(s): Dorman, Daniel B ;
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K,Ca; I CAN; I A, slow; Na/Ca exchanger; I Krp; I R; Ca pump; Kir; IK Bkca; IK Skca; Gaba; Glutamate;
//genesis

/***************************		MS Model, Version 9.1	**********************
**************************** 	      	globals.g 			**********************

******************************************************************************/
//Updated 6 November 2014 by Dan Dorman: ELEAK, RA, RM, CM, EREST_ACT, somaLen,gKIRsoma_UI, gKIRdend_UI were updated following optimization to hyperpolarized experimental current injection responses and changing soma morphology to cylindrical
str compartment = "compartment" //set compartment type
//Careful - all of these can be overridden in the .p file
if ({GABAtonic})
    float ELEAK = -.18//.29
else
    float ELEAK = -.072//-0.029478
end
float PI = 3.1415926
float RA = 1.25//13.7657 Range = 1 - 3
float RM = 1.875//8.97763 Range from KochSegev p175 = 2 - 10
float CM = 0.01//0.035  Range = .005 to .015
float EREST_ACT = -0.086//-.087
float TEMPERATURE = 35
float GHKluge=1e-7  //This param is required because getglobals only has 6 figs to right of decimal
                    //dividing by GHKluge is reversed in AddCaSpines.g and 
//parameters determined by hand tuning to match spike width, AHP shape &amp, fI curve

float somaLen=11.3137e-6 
float prox=26.1e-6// Primary only//42.1e-6 //26.1e-6 //primary and secondary
float mid=37.4e-6// Secondary and Teriary//60.1e-6 //62.1e-6 //tert1 
float dist=1000e-6

	float gNaFsoma_D1={47500}    //50000 0.95x
        float gNaFprox_D1={2593}     //5700 6000	//includes mid
        float gNaFdist_D1={926}     //1900 2000	

	float gNaFsoma_D2={55000}    //50000 1.1x
        float gNaFprox_D2={2730}     //6000	//includes mid
        float gNaFdist_D2={975}     //2000	

	float gNaFsoma_D1PD={47500}    //50000 0.95x
        float gNaFprox_D1PD={2593}     //6000	//includes mid
        float gNaFdist_D1PD={926}     //2000	

	float gNaFsoma_D2PD={55000}    //55000 1.1x
        float gNaFprox_D2PD={2730}     //6600	//includes mid
        float gNaFdist_D2PD={975}     //2200	

	float gNaFsoma_UI={46000}    //50000 1.1x
        float gNaFprox_UI={2600}     //6000	//includes mid
        float gNaFdist_UI={0}     //2000	


/*This set of KAf*/
        float gKAfsoma_UI={200}      //{300}

        float gKAfprox_UI={200} //{550}
        float gKAfdist_UI = {200}
	//If gKAfdend is too low, get bursting, if too high, no spikes

	float gKAfsoma_D1={200}      //{300}

        float gKAfdend_D1={100} //{550}
	//If gKAfdend is too low, get bursting, if too high, no spikes

	float gKAfsoma_D2={200}      //{300}

        float gKAfdend_D2={100} //{550}
	//If gKAfdend is too low, get bursting, if too high, no spikes

	float gKAfsoma_D1PD={200}      //{300}

        float gKAfdend_D1PD={100} //{550}

	float gKAfsoma_D2PD={200}      //{300}
	float gKAfdend_D2PD={56} //{550}


        float gKAssoma_D1={250}  
        float gKAsdend_D1={38.93}  //includes mid 

	float gKAssoma_D2={275}  //220 1.1x 
        float gKAsdend_D2={47.02} //22 //includes mid 

	float gKAssoma_D1PD={250}  
        float gKAsdend_D1PD={38.93}  //includes mid 

	float gKAssoma_D2PD={275}  //220 1.1x 
        float gKAsdend_D2PD={47.02} //22.2 //includes mid 

	float gKAssoma_UI={12}  //220 1.1x 
        float gKAsdend_UI={12} //22 //includes mid 
//Has effect on number of spikes, but not AHP amplitude

//Need to repeat sims with gKAs blocked - similar results to Shen .. Surmeier?

        float gKIRsoma_D1={31.3322} //{11} 1.25x        
        float gKIRdend_D1={31.3322}

	float gKIRsoma_D2={25.0658} //{11}        
        float gKIRdend_D2={25.0658}

	float gKIRsoma_D1PD={31.3322} //{11} 1.25x        
        float gKIRdend_D1PD={31.3322}

	float gKIRsoma_D2PD={25.0658} //{11}        
        float gKIRdend_D2PD={25.0658}

	float gKIRsoma_UI={8.5} //{11}        
        float gKIRdend_UI={8.5}

	float gKrpsoma={9}  //10.008 is 14    
	float gKrpdend={8}
//Has effect on number of spikes, but not AHP amplitude

//Better to lower this and raise gKAs?

	float gBKsoma={8}
	float gBKdend={8}
//Higher value gave better AHPs.  
//Increase in gBKsoma was compensated by lower gKAfdend and gKAssoma
//Perhaps a bit too high - does this prevent KAs from doing its thing?

	float gSKsoma={1}
	float gSKdend={1}

	float gCaL13soma_D1 = {{3e-7}/{GHKluge}}  //{{6e-7}/{Cafactor}}  		
	float gCaL13dend_D1 = {{0.5e-8}/{GHKluge}} //{{gCaL13soma}/{Dendfactor}} 

	float gCaL13soma_D2 = {{0.75}*{3e-7}/{GHKluge}}  //{{6e-7}/{Cafactor}}  //0.75x		
	float gCaL13dend_D2 = {{0.75}*{0.5e-8}/{GHKluge}} //{{gCaL13soma}/{Dendfactor}} 

	float gCaL13soma_D1PD = {{3e-7}/{GHKluge}}  //{{6e-7}/{Cafactor}}  		
	float gCaL13dend_D1PD = {{0.5e-8}/{GHKluge}} //{{gCaL13soma}/{Dendfactor}} 

	float gCaL13soma_D2PD = {{0.75}*{3e-7}/{GHKluge}}  //{{6e-7}/{Cafactor}}  //0.75x		
	float gCaL13dend_D2PD = {{0.75}*{0.5e-8}/{GHKluge}} //{{gCaL13soma}/{Dendfactor}} 

	float gCaL13soma_UI = {{2e-7}/{GHKluge}}  //{{6e-7}/{Cafactor}}  		
	float gCaL13dend_UI = {{2e-7}/{GHKluge}} //{{gCaL13soma}/{Dendfactor}} 
	
	float gCaT32prox  =  {{0e-8}/{GHKluge}} //{{10e-8}/{Cafactor}}         
	float gCaT32dist  =  {{1e-7}/{GHKluge}} 

	float gCaT33prox  =  {{0e-8}/{GHKluge}} //{{10e-8}/{Cafactor}}         
	float gCaT33dist  =  {{.5e-8}/{GHKluge}} 


	float gCaRsoma  =  {{3e-7}/{GHKluge}} //{{18e-7}/{Cafactor}}		
	float gCaRdend  =  {{5e-7}/{GHKluge}} //{{gCaRsoma}/{Dendfactor}}	

	float gCaNsoma =   {{1e-8}/{GHKluge}} //{{10e-7}/{Cafactor}}       
	float gCaNdend =   {{0}/{GHKluge}} //{{gCaNsoma}/{Dendfactor}}       

	float gCaL12soma_D1 = {{2}*{6e-7}/{GHKluge}} //{{6e-7}/{Cafactor}} //2x   	
	float gCaL12dend_D1 = {{2}*{1e-7}/{GHKluge}} //{{gCaL12soma}/{Dendfactor}} 

	float gCaL12soma_D2 = {{6e-7}/{GHKluge}} //{{6e-7}/{Cafactor}}    	
	float gCaL12dend_D2 = {{1e-7}/{GHKluge}} //{{gCaL12soma}/{Dendfactor}} 

	float gCaL12soma_D1PD = {{2}*{6e-7}/{GHKluge}} //{{6e-7}/{Cafactor}} //2x   	
	float gCaL12dend_D1PD = {{2}*{1e-7}/{GHKluge}} //{{gCaL12soma}/{Dendfactor}} 

	float gCaL12soma_D2PD = {{6e-7}/{GHKluge}} //{{6e-7}/{Cafactor}}    	
	float gCaL12dend_D2PD = {{1e-7}/{GHKluge}} //{{gCaL12soma}/{Dendfactor}} 

	float gCaL12soma_UI = {{1e-7}/{GHKluge}} //{{6e-7}/{Cafactor}}    	
	float gCaL12dend_UI = {{1e-7}/{GHKluge}} //{{gCaL12soma}/{Dendfactor}} 
    

	float gtonicGABAdend={650e-2} //tonic GABA parameters//1300e-2
    float x0GABA = 40e-6 //sigmoidal function parameters//20e-6

    float kGABA = 0.8e-4

float qfactorKir = 1.2   
float qfactorKrp = 3   //3 2
float qfactorNaF = 2.5  //2.5  1.7
float qfactorkAs=2     //3  2
float qfactorkAf=2   //1.5  1.5
float qfactCa = 2      //3  2
//bk and sk qfacts are taken into account in their channel files.