Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)

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Accession:245411
We use a computational model of a striatal spiny projection neuron to investigate dendritic spine calcium dynamics in response to spatiotemporal patterns of synaptic inputs. We show that spine calcium elevation is stimulus-specific, with supralinear calcium elevation in cooperatively stimulated spines. Intermediate calcium elevation occurs in neighboring non-stimulated dendritic spines, predicting heterosynaptic effects. Inhibitory synaptic inputs enhance the difference between peak calcium in stimulated spines, and peak calcium in non-stimulated spines, thereby enhancing stimulus specificity.
Reference:
1 . Dorman DB, Jedrzejewska-Szmek J, Blackwell KT (2018) Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model. Elife, Kennedy, Mary B, ed. [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Basal ganglia;
Cell Type(s): Neostriatum spiny neuron;
Channel(s): Ca pump; Kir; I A; I A, slow; I CAN; I K,Ca; I Krp; I Na,t; I L high threshold; I R; I T low threshold; IK Bkca; IK Skca; Na/Ca exchanger;
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s): Cav3.2 CACNA1H; Cav3.3 CACNA1I; Cav1.2 CACNA1C; Cav1.3 CACNA1D; Cav2.2 CACNA1B; Kv4.2 KCND2; Kir2.1 KCNJ2; Kv2.1 KCNB1;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Calcium dynamics; Detailed Neuronal Models; Synaptic Integration; Synaptic Plasticity;
Implementer(s): Dorman, Daniel B ;
Search NeuronDB for information about:  GabaA; AMPA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K,Ca; I CAN; I A, slow; Na/Ca exchanger; I Krp; I R; Ca pump; Kir; IK Bkca; IK Skca; Gaba; Glutamate;
//genesis
//include_channels.g v9.1
/*******
Rebekah Evans updated 3/20/12
include_channels.g is included in proto.g file
**********/

include MScell/channels/tabchanforms.g
include MScell/channels/CDI-GHK.g

//voltage dependent channels
include MScell/channels/NaF	
include MScell/channels/NaFslowinact		//double checked RCE 3/23/12, realized htau has qfact 2 taken into account, but not mtau. no changes made, but will test qfact
include MScell/channels/KaF  			//double checked RCE 3/21/12 fine, no changes.  triple checked with genesis _____
include MScell/channels/Kir			//double checked RCE 3/22/12 fine, no changes. triple checked with genesis ____
include MScell/channels/KaS			//double checked RCE 3/22/12 fine, no changes. triple checked with genesis _____
include MScell/channels/Krp			//adjusted 3/22/12 RCE double checked _____ triple checked with genesis _____

//calcium channels
include MScell/channels/CaL12CDI  	//adjusted 3/20/12 RCE double checked _______  triple checked with genesis _____
include MScell/channels/CaL13CDI  	//adjusted 3/20/12 RCE double checked _______ triple checked with genesis _____
include MScell/channels/CaNCDI		  //adjusted 3/20/12 RCE double checked _______ triple checked with genesis _____
include MScell/channels/CaRCDI		  //adjusted 3/20/12 RCE double checked _______ triple checked with genesis _____
include MScell/channels/CaT32 	 	 //adjusted 3/20/12 RCE double checked _______ triple checked with genesis _____
include MScell/channels/CaT33 	 	 //adjusted 3/20/12 RCE double checked _______ triple checked with genesis _____



//calcium dependent potassium channels
include MScell/channels/BK			//double checked RCE 3/22/12 fine, no changes made.  
include MScell/channels/SK			//double checked RCE 3/23/12 fine, no changes made.  
include MScell/channels/GABA_tonic