An updated stochastic model of cerebellar Long-Term Depression (LTD) to study the requirements of calcium to induce LTD. Calcium signal is generated as a train of calcium pulses and this can be modulated by its amplitude, frequency, width and number of pulses.
CaMKII activation and its regulatory pathway are added to an earlier published model to study the sensitivity to calcium frequency. The model is useful to investigate systematically the dependence of LTD induction on calcium stimuli parameters.
Zamora Chimal CG, De Schutter E (2018) Ca2+ Requirements for Long-Term Depression Are Frequency Sensitive in Purkinje Cells. Front Mol Neurosci 11:438 [PubMed]