Hippocampal Mossy Fiber bouton: presynaptic KV7 channel function (Martinello et al 2019)

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Accession:245417

Reference:
1 . Martinello K, Giacalone E, Migliore M, Brown DA, Shah MM (2019) The subthreshold-active KV7 current limits spike-induced Ca2+ influx in hippocampal mossy fiber synaptic terminals to regulate neurotransmission Communications Biology, in press
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Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s):
Channel(s): I A; I CAN; I K,leak; I M; I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potentials;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu]; Giacalone, Elisabetta [elisabetta.giacalone at pa.ibf.cnr.it];
Search NeuronDB for information about:  AMPA; I Na,t; I A; I K; I K,leak; I M; I CAN; Glutamate;
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modeldb_Kv7_MFB
README.html
cacumm.mod *
can2t.mod
kaprox.mod *
kdrca1.mod *
kir.mod
kmb.mod *
naxn_J.mod
fig4_modeldb.hoc
fig4_modeldb.ses
mosinit.hoc
screenshot1.png
screenshot2.png
                            
TITLE CA1 KM channel from Mala Shah
: M. Migliore June 2006

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)

}

PARAMETER {
	v 		(mV)
	ek
	celsius 	(degC)
	gbar=.0001 	(mho/cm2)
        vhalfl=-40   	(mV)
	kl=-10
        vhalft=-42   	(mV)
        a0t=0.003      	(/ms)
        zetat=7    	(1)
        gmt=.4   	(1)
	q10=5
	b0=60
	st=1
	sh =0
}


NEURON {
	SUFFIX kmb
	USEION k READ ek WRITE ik
        RANGE  gbar,ik, sh
      GLOBAL inf, tau
}

STATE {
        m
}

ASSIGNED {
	ik (mA/cm2)
        inf
	tau
        taua
	taub
}

INITIAL {
	rate(v)
	m=inf
}


BREAKPOINT {
	SOLVE state METHOD cnexp
	ik = gbar*m^st*(v-ek)
}


FUNCTION alpt(v(mV)) {
  alpt = exp(0.0378*zetat*(v-vhalft-sh)) 
}

FUNCTION bett(v(mV)) {
  bett = exp(0.0378*zetat*gmt*(v-vhalft-sh)) 
}

DERIVATIVE state {
        rate(v)
	m' = (inf - m)/tau
}

PROCEDURE rate(v (mV)) { :callable from hoc
        LOCAL a,qt
        qt=q10^((celsius-35)/10)
        inf = (1/(1 + exp((v-vhalfl-sh)/kl)))
        a = alpt(v)
        tau = b0 + bett(v)/(a0t*(1+a))
}