CA1 network model for place cell dynamics (Turi et al 2019)

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Accession:246546
Biophysical model of CA1 hippocampal region. The model simulates place cells/fields and explores the place cell dynamics as function of VIP+ interneurons.
Reference:
1 . Turi GF, Li W, Chavlis S, Pandi I, O’Hare J, Priestley JB, Grosmark AD, Liao Z, Ladow M, Zhang JF, Zemelman BV, Poirazi P, Losonczy A (2019) Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Hippocampus Support Goal-Oriented Spatial Learning Neuron
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus; Mouse;
Cell Type(s): Hippocampus CA1 pyramidal cell; Hippocampus CA1 basket cell; Hippocampus CA1 basket cell - CCK/VIP; Hippocampus CA1 bistratified cell; Hippocampus CA1 axo-axonic cell; Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ; Hippocampal CA1 CR/VIP cell;
Channel(s): I A; I h; I K,Ca; I Calcium; I Na, leak; I K,leak; I M;
Gap Junctions:
Receptor(s): GabaA; GabaB; NMDA; AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Brian;
Model Concept(s): Place cell/field;
Implementer(s): Chavlis, Spyridon [schavlis at imbb.forth.gr]; Pandi, Ioanna ;
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; GabaA; GabaB; AMPA; NMDA; I A; I K,leak; I M; I h; I K,Ca; I Calcium; I Na, leak;
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Turi_et_al_2018
mechanisms
ANsyn.mod
bgka.mod
burststim2.mod *
cad.mod
cadyn.mod
cadyn_new.mod
cagk.mod *
cal.mod
calH.mod *
cancr.mod
car.mod *
cat.mod
ccanl.mod *
gskch.mod
h.mod
hha_old.mod *
hha2.mod
hNa.mod *
IA.mod
iccr.mod
ichan2.mod
ichan2aa.mod
ichan2bc.mod
ichan2bs.mod
ichan2vip.mod
Ih.mod *
Ihvip.mod
ikscr.mod *
kad.mod *
kadistcr.mod
kap.mod
Kaxon.mod
kca.mod
Kdend.mod
kdrcr.mod *
km.mod
Ksoma.mod
LcaMig.mod *
my_exp2syn.mod
Naaxon.mod
Nadend.mod
nafcr.mod *
nap.mod
Nasoma.mod
nca.mod *
nmda.mod
regn_stim.mod
somacar.mod
STDPE2Syn.mod *
vecstim.mod *
                            
COMMENT
km.mod
Potassium channel, Hodgkin-Huxley style kinetics
Based on I-M (muscarinic K channel)
Slow, noninactivating
Author: Zach Mainen, Salk Institute, 1995, zach@salk.edu
	
ENDCOMMENT

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

NEURON {
	SUFFIX km
	USEION k READ ek WRITE ik
	RANGE n, gk, gbar
	RANGE ninf, ntau
	GLOBAL Ra, Rb
	GLOBAL q10, temp, tadj, vmin, vmax
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(pS) = (picosiemens)
	(um) = (micron)
} 

PARAMETER {
	v 		(mV)
	dt		(ms)
	gbar = 10   	(pS/um2)	: 0.03 mho/cm2
	tha  = -30	(mV)		: v 1/2 for inf
	qa   = 9	(mV)		: inf slope		
	Ra   = 0.001	(/ms)		: max act rate  (slow)
	Rb   = 0.001	(/ms)		: max deact rate  (slow)
	celsius		(degC)
	temp = 23	(degC)		: original temp 	
	q10  = 2.3			: temperature sensitivity
	vmin = -120	(mV)
	vmax = 100	(mV)
} 


ASSIGNED {
	a		(/ms)
	b		(/ms)
	ik 		(mA/cm2)
	gk		(pS/um2)
	ek		(mV)
	ninf
	ntau (ms)	
	tadj
}
 

STATE { n }

INITIAL { 
	trates(v)
	n = ninf
}

BREAKPOINT {
	SOLVE states
	gk = tadj*gbar*n
	ik = (1e-4) * gk * (v - ek)
} 

LOCAL nexp

PROCEDURE states() {   : Computes state variable n 
        trates(v)      : at the current v and dt.
        n = n + nexp*(ninf-n)
        VERBATIM
        return 0;
        ENDVERBATIM
}

PROCEDURE trates(v) {  
	:Computes rate and other constants at current v.
	:Call once from HOC to initialize inf at resting v.
	LOCAL tinc
	TABLE ninf, nexp
	DEPEND dt, celsius, temp, Ra, Rb, tha, qa

	FROM vmin TO vmax WITH 199

	rates(v): not consistently executed from here if usetable_hh == 1
	tadj = q10^((celsius - temp)/10)  :temperature adjastment
	tinc = -dt * tadj
	nexp = 1 - exp(tinc/ntau)
}


PROCEDURE rates(v) {  
	:Computes rate and other constants at current v.
	:Call once from HOC to initialize inf at resting v.
	a = Ra * (v - tha) / (1 - exp(-(v - tha)/qa))
	b = -Rb * (v - tha) / (1 - exp((v - tha)/qa))
	ntau = 1/(a+b)
	ninf = a*ntau
}