CA1 network model for place cell dynamics (Turi et al 2019)

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Accession:246546
Biophysical model of CA1 hippocampal region. The model simulates place cells/fields and explores the place cell dynamics as function of VIP+ interneurons.
Reference:
1 . Turi GF, Li W, Chavlis S, Pandi I, O’Hare J, Priestley JB, Grosmark AD, Liao Z, Ladow M, Zhang JF, Zemelman BV, Poirazi P, Losonczy A (2019) Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Hippocampus Support Goal-Oriented Spatial Learning Neuron
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus; Mouse;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 basket cell; Hippocampus CA1 basket cell - CCK/VIP; Hippocampus CA1 bistratified cell; Hippocampus CA1 axo-axonic cell; Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ; Hippocampal CA1 CR/VIP cell;
Channel(s): I A; I h; I K,Ca; I Calcium; I Na, leak; I K,leak; I M;
Gap Junctions:
Receptor(s): GabaA; GabaB; NMDA; AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Brian;
Model Concept(s): Place cell/field;
Implementer(s): Chavlis, Spyridon [schavlis at imbb.forth.gr]; Pandi, Ioanna ;
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; GabaB; AMPA; NMDA; I A; I K,leak; I M; I h; I K,Ca; I Calcium; I Na, leak;
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Turi_et_al_2018
mechanisms
ANsyn.mod
bgka.mod
burststim2.mod *
cad.mod
cadyn.mod
cadyn_new.mod
cagk.mod *
cal.mod
calH.mod *
cancr.mod
car.mod *
cat.mod
ccanl.mod *
gskch.mod
h.mod
hha_old.mod *
hha2.mod
hNa.mod *
IA.mod
iccr.mod
ichan2.mod
ichan2aa.mod
ichan2bc.mod
ichan2bs.mod
ichan2vip.mod
Ih.mod *
Ihvip.mod
ikscr.mod *
kad.mod *
kadistcr.mod
kap.mod
Kaxon.mod
kca.mod
Kdend.mod
kdrcr.mod *
km.mod
Ksoma.mod
LcaMig.mod *
my_exp2syn.mod
Naaxon.mod
Nadend.mod
nafcr.mod *
nap.mod
Nasoma.mod
nca.mod *
nmda.mod
regn_stim.mod
somacar.mod
STDPE2Syn.mod *
vecstim.mod *
                            
: Fast Na+ channel

NEURON {
	SUFFIX Nafcr
	USEION na READ ena WRITE ina
	RANGE gnafbar, ina, gna
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	
}

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

PARAMETER {
	v (mV)
	dt (ms)
	gnafbar= 0.086 (mho/cm2) <0,1e9>
	ena = 55 (mV)

}
STATE {
	m h
}
ASSIGNED {
	ina (mA/cm2)
	minf hinf 
	mtau (ms)
	htau (ms)
	gna (mho/cm2)
	
}



INITIAL {
	rate(v)
	m = minf
	h = hinf
}

BREAKPOINT {
	SOLVE states METHOD cnexp
	gna = gnafbar*m*m*m*h
	ina = gna*(v-55)
	
}

DERIVATIVE states {
	rate(v)
	m' = (minf-m)/mtau
	h' = (hinf-h)/htau
}

UNITSOFF

FUNCTION malf( v){ LOCAL va 
	va=v+28
	if (fabs(va)<1e-04){
	   malf= -0.2816*(-9.3 + va*0.5)
	}else{
	   malf = -0.2816*(v+28)/(-1+exp(-(v+28)/9.3))
	}
}


FUNCTION mbet(v(mV))(/ms) { LOCAL vb 
	vb=v+1
	if (fabs(vb)<1e-04){
	   mbet = 0.2464*(6 + vb*0.5)
	}else{
	   mbet = 0.2464*(v+1)/(-1+exp((v+1)/6))
}
}	


FUNCTION half(v(mV))(/ms) { LOCAL vc 
	vc=v+43.1
	if (fabs(vc)<1e-04){
	   half=0.098*(20 + vc*0.5)
	}else{
	   half=0.098/exp((v+23.1)/20) :was 43.1
}
}


FUNCTION hbet(v(mV))(/ms) { LOCAL vd
	vd=v+13.1
	if (fabs(vd)<1e-04){
	   hbet=1.4*(10 + vd*0.5)
	}else{
	   hbet=1.4/(1+exp(-(v+25.1)/10)) :was 13.1 changed july 30, 2007
} 
}




PROCEDURE rate(v (mV)) {LOCAL q10, msum, hsum, ma, mb, ha, hb
	

	ma=malf(v) mb=mbet(v) ha=half(v) hb=hbet(v)
	
	msum = ma+mb
	minf = ma/msum
	mtau = 1/(msum)
	
	
	hsum=ha+hb
	hinf=ha/hsum
	htau = 1 / (hsum)
	
}

	
UNITSON