CA1 network model for place cell dynamics (Turi et al 2019)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:246546
Biophysical model of CA1 hippocampal region. The model simulates place cells/fields and explores the place cell dynamics as function of VIP+ interneurons.
Reference:
1 . Turi GF, Li W, Chavlis S, Pandi I, O’Hare J, Priestley JB, Grosmark AD, Liao Z, Ladow M, Zhang JF, Zemelman BV, Poirazi P, Losonczy A (2019) Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Hippocampus Support Goal-Oriented Spatial Learning Neuron
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus; Mouse;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 basket cell; Hippocampus CA1 basket cell - CCK/VIP; Hippocampus CA1 bistratified cell; Hippocampus CA1 axo-axonic cell; Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ; Hippocampal CA1 CR/VIP cell;
Channel(s): I A; I h; I K,Ca; I Calcium; I Na, leak; I K,leak; I M;
Gap Junctions:
Receptor(s): GabaA; GabaB; NMDA; AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Brian;
Model Concept(s): Place cell/field;
Implementer(s): Chavlis, Spyridon [schavlis at imbb.forth.gr]; Pandi, Ioanna ;
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; GabaA; GabaB; AMPA; NMDA; I A; I K,leak; I M; I h; I K,Ca; I Calcium; I Na, leak;
/
Turi_et_al_2018
mechanisms
ANsyn.mod *
bgka.mod *
burststim2.mod *
cad.mod
cadyn.mod *
cadyn_new.mod *
cagk.mod *
cal.mod *
calH.mod *
cancr.mod *
car.mod *
cat.mod *
ccanl.mod *
gskch.mod *
h.mod *
hha_old.mod *
hha2.mod *
hNa.mod *
IA.mod *
iccr.mod *
ichan2.mod *
ichan2aa.mod *
ichan2bc.mod *
ichan2bs.mod *
ichan2vip.mod *
Ih.mod *
Ihvip.mod *
ikscr.mod *
kad.mod *
kadistcr.mod *
kap.mod *
Kaxon.mod *
kca.mod *
Kdend.mod *
kdrcr.mod *
km.mod *
Ksoma.mod *
LcaMig.mod *
my_exp2syn.mod *
Naaxon.mod *
Nadend.mod *
nafcr.mod *
nap.mod *
Nasoma.mod *
nca.mod *
nmda.mod *
regn_stim.mod *
somacar.mod *
STDPE2Syn.mod *
vecstim.mod *
                            
TITLE nap

COMMENT
Sodium Channels in AP Initiation of CA1 Pyramidal Neurons (Royeck et al. 2008)
ENDCOMMENT

NEURON {
	SUFFIX nap
	USEION na READ ena WRITE ina
	RANGE  gbar, timestauh, timestaum, shifttaum, shifttauh, thegna
	GLOBAL minf, mtau 

}

PARAMETER {
	gbar = .0052085   	(mho/cm2)
	
	:q10m=3.1
	:q10h=2.3
	
	timestauh=1
	timestaum=1
	shifttaum=1
	shifttauh=1
	
	
	eNa = 55 	(mV)		:Golomb et al.
	ena		(mV)            : must be explicitly def. in hoc
	celsius (degC)
	v 		(mV)
}


UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(pS) = (picosiemens)
	(um) = (micron)
} 

ASSIGNED {
	ina 		(mA/cm2)
	thegna		(mho/cm2)
	minf 		:hinf 		
	mtau (ms)	:htau (ms) 	
}
 

STATE { m }


UNITSOFF

BREAKPOINT {
    SOLVE states METHOD cnexp
	mtau = 1
	minf = (1/(1+exp(-(v+52.3)/6.8))) :midpoint -56.3, slope 7.4	        		
	
	thegna =gbar*m       

	ina = thegna * (v - eNa)
	} 

INITIAL {

	mtau = 1
	minf = (1/(1+exp(-(v+52.3)/6.8))) :midpoint - 52.3 slope 6.8	5.5	        	
	m=minf  

}

DERIVATIVE states {   
  
	mtau = 1
	minf = (1/(1+exp(-(v+52.3)/6.8))) :midpoint - 52.3 (47) slope 6.8	         	
	m' = (minf-m)/mtau


}



UNITSON