CA1 network model for place cell dynamics (Turi et al 2019)

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Accession:246546
Biophysical model of CA1 hippocampal region. The model simulates place cells/fields and explores the place cell dynamics as function of VIP+ interneurons.
Reference:
1 . Turi GF, Li W, Chavlis S, Pandi I, O’Hare J, Priestley JB, Grosmark AD, Liao Z, Ladow M, Zhang JF, Zemelman BV, Poirazi P, Losonczy A (2019) Vasoactive Intestinal Polypeptide-Expressing Interneurons in the Hippocampus Support Goal-Oriented Spatial Learning Neuron
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Hippocampus; Mouse;
Cell Type(s): Hippocampus CA1 pyramidal cell; Hippocampus CA1 basket cell; Hippocampus CA1 basket cell - CCK/VIP; Hippocampus CA1 bistratified cell; Hippocampus CA1 axo-axonic cell; Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ; Hippocampal CA1 CR/VIP cell;
Channel(s): I A; I h; I K,Ca; I Calcium; I Na, leak; I K,leak; I M;
Gap Junctions:
Receptor(s): GabaA; GabaB; NMDA; AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Brian;
Model Concept(s): Place cell/field;
Implementer(s): Chavlis, Spyridon [schavlis at imbb.forth.gr]; Pandi, Ioanna ;
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; GabaA; GabaB; AMPA; NMDA; I A; I K,leak; I M; I h; I K,Ca; I Calcium; I Na, leak;
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Turi_et_al_2018
mechanisms
ANsyn.mod
bgka.mod
burststim2.mod *
cad.mod
cadyn.mod
cadyn_new.mod
cagk.mod *
cal.mod
calH.mod *
cancr.mod
car.mod *
cat.mod
ccanl.mod *
gskch.mod
h.mod
hha_old.mod *
hha2.mod
hNa.mod *
IA.mod
iccr.mod
ichan2.mod
ichan2aa.mod
ichan2bc.mod
ichan2bs.mod
ichan2vip.mod
Ih.mod *
Ihvip.mod
ikscr.mod *
kad.mod *
kadistcr.mod
kap.mod
Kaxon.mod
kca.mod
Kdend.mod
kdrcr.mod *
km.mod
Ksoma.mod
LcaMig.mod *
my_exp2syn.mod
Naaxon.mod
Nadend.mod
nafcr.mod *
nap.mod
Nasoma.mod
nca.mod *
nmda.mod
regn_stim.mod
somacar.mod
STDPE2Syn.mod *
vecstim.mod *
                            
COMMENT
	calcium accumulation into a volume of area*depth next to the
	membrane with a decay (time constant tau) to resting level
	given by the global calcium variable cai0_ca_ion
ENDCOMMENT

NEURON {
	SUFFIX ccanl
USEION nca READ ncai, inca, enca WRITE enca, ncai VALENCE 2
USEION lca READ lcai, ilca, elca WRITE elca, lcai VALENCE 2
USEION tca READ tcai, itca, etca WRITE etca, tcai VALENCE 2
RANGE caiinf, catau, cai, ncai, lcai,tcai, eca, elca, enca, etca
}

UNITS {
        (mV) = (millivolt)
	(molar) = (1/liter)
	(mM) = (milli/liter)
	(mA) = (milliamp)
	FARADAY = 96520 (coul)
	R = 8.3134	(joule/degC)
}

INDEPENDENT {t FROM 0 TO 100 WITH 100 (ms)}

PARAMETER {
        celsius = 6.3 (degC)
	depth = 200 (nm)	: assume volume = area*depth
	catau = 9 (ms)
	caiinf = 50.e-6 (mM)	: takes precedence over cai0_ca_ion
			: Do not forget to initialize in hoc if different
			: from this default.
	cao = 2 (mM)
	ica (mA/cm2)
	inca (mA/cm2)
	ilca (mA/cm2)
	itca (mA/cm2)
	cai= 50.e-6 (mM)
}

ASSIGNED {
	enca (mV)
	elca (mV)
	etca (mV)
	eca (mV)
}

STATE {
	ncai (mM)
	lcai (mM)
	tcai (mM)
}

INITIAL {
	VERBATIM
	ncai = _ion_ncai;
	lcai = _ion_lcai;
	tcai = _ion_tcai; 
	ENDVERBATIM
	ncai=caiinf/3
	lcai=caiinf/3
	tcai=caiinf/3
	cai = caiinf	
	eca = ktf() * log(cao/caiinf)	
	enca = eca
	elca = eca
	etca = eca
}


BREAKPOINT {
	SOLVE integrate METHOD derivimplicit
	cai = ncai+lcai+tcai	
	eca = ktf() * log(cao/cai)	
	enca = eca
	elca = eca
	etca = eca
}

DERIVATIVE integrate {
ncai' = -(inca)/depth/FARADAY * (1e7) + (caiinf/3 - ncai)/catau
lcai' = -(ilca)/depth/FARADAY * (1e7) + (caiinf/3 - lcai)/catau
tcai' = -(itca)/depth/FARADAY * (1e7) + (caiinf/3 - tcai)/catau
}

FUNCTION ktf() (mV) {
	ktf = (1000)*R*(celsius +273.15)/(2*FARADAY)
}