A phantom bursting mechanism for episodic bursting (Bertram et al 2008)


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Accession:247646
"We describe a novel dynamic mechanism for episodic or compound bursting oscillations, in which bursts of electrical impulses are clustered together into episodes, separated by long silent phases. We demonstrate the mechanism for episodic bursting using a minimal mathematical model for “phantom bursting.” Depending on the location in parameter space, this model can produce fast, medium, or slow bursting, or in the present case, fast, slow, and episodic bursting. The episodic bursting is modestly robust to noise and to parameter variation, and the effect that noise has on the episodic bursting pattern is quite different from that of an alternate episodic burst mechanism in which the slow envelope is produced by metabolic oscillations. This mechanism could account for episodic bursting produced in endocrine cells or neurons, such as pancreatic islets or gonadotropin releasing neurons of the hypothalamus."
Reference:
1 . Bertram R, Rhoads J, Cimbora WP (2008) A phantom bursting mechanism for episodic bursting. Bull Math Biol 70:1979-93 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type:
Brain Region(s)/Organism:
Cell Type(s): Hodgkin-Huxley neuron;
Channel(s): I K; I Potassium; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP (web link to model); CellML (web link to model);
Model Concept(s): Oscillations; Parameter Fitting; Activity Patterns; Bursting;
Implementer(s):
Search NeuronDB for information about:  I K; I Calcium; I Potassium;
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