Ca2+ Oscillations in Sympathetic neurons (Friel 1995)


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Accession:247655
" ... This study focuses on caffeine-induced [Ca2+]i oscillations in sympathetic neurons. ... The aim of the study was to understand the mechanism responsible for the oscillations. As a starting point, [Ca2+]i relaxations were examined after membrane depolarization and exposure to caffeine. For both stimuli, post-stimulus relaxations could be described by the sum of two decaying exponential functions, consistent with a one-pool system in which Ca2+ transport between compartments is regulated by linear Ca2+ pumps and leaks. After modifying the store to include a [Ca2+]i-sensitive leak, the model also exhibits oscillations such as those observed experimentally. ... Thus, a one-pool model with a single [Ca2+]i-sensitive Ca2+ permeability is adequate to account for many of the quantitative properties of steady-state [Ca2+]i oscillations in sympathetic neurons. ..."
Reference:
1 . Friel DD (1995) [Ca2+]i oscillations in sympathetic neurons: an experimental test of a theoretical model. Biophys J 68:1752-66 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Extracellular; Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Calcium; Ca pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: CellML (web link to model);
Model Concept(s): Calcium dynamics; Activity Patterns; Oscillations;
Implementer(s):
Search NeuronDB for information about:  I Calcium; Ca pump;
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