Visual physiology of the layer 4 cortical circuit in silico (Arkhipov et al 2018)


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Accession:247848
"Despite advances in experimental techniques and accumulation of large datasets concerning the composition and properties of the cortex, quantitative modeling of cortical circuits under in-vivo-like conditions remains challenging. Here we report and publicly release a biophysically detailed circuit model of layer 4 in the mouse primary visual cortex, receiving thalamo- cortical visual inputs. The 45,000-neuron model was subjected to a battery of visual stimuli, and results were compared to published work and new in vivo experiments. ..."
Reference:
1 . Arkhipov A, Gouwens NW, Billeh YN, Gratiy S, Iyer R, Wei Z, Xu Z, Abbasi-Asl R, Berg J, Buice M, Cain N, da Costa N, de Vries S, Denman D, Durand S, Feng D, Jarsky T, Lecoq J, Lee B, Li L, Mihalas S, Ocker GK, Olsen SR, Reid RC, Soler-Llavina G, Sorensen SA, Wang Q, Waters J, Scanziani M, Koch C (2018) Visual physiology of the layer 4 cortical circuit in silico. PLoS Comput Biol 14:e1006535 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 interneuron chandelier SOM cell; Neocortex V1 interneuron basket PV cell; Neocortex layer 4 pyramidal cell;
Channel(s): I L high threshold; I T low threshold; I M; I Krp; I K; I Na,p; I Na,t; IK Skca;
Gap Junctions:
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Simulation Environment: NEURON (web link to model); BioNet (web link to model);
Model Concept(s): Simplified Models; Detailed Neuronal Models; Brain Rhythms; Gamma oscillations; Triggered activity; Activity Patterns; Orientation selectivity;
Implementer(s):
Search NeuronDB for information about:  Neocortex V1 interneuron basket PV cell; Neocortex V1 interneuron chandelier SOM cell; I Na,p; I Na,t; I L high threshold; I T low threshold; I K; I M; I Krp; IK Skca;
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