Pancreatic Beta Cell signalling pathways (Fridlyand & Philipson 2016) (MATLAB)

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Accession:248313
This is a 3rd party implementation of Fridlyand & Philipson 2016 who's abstract begins "Insulin secretory in pancreatic beta-cells responses to nutrient stimuli and hormonal modulators include multiple messengers and signaling pathways with complex interdependencies. Here we present a computational model that incorporates recent data on glucose metabolism, plasma membrane potential, G-protein-coupled-receptors (GPCR), cytoplasmic and endoplasmic reticulum calcium dynamics, cAMP and phospholipase C pathways that regulate interactions between second messengers in pancreatic beta-cells. The values of key model parameters were inferred from published experimental data. The model gives a reasonable fit to important aspects of experimentally measured metabolic and second messenger concentrations and provides a framework for analyzing the role of metabolic, hormones and neurotransmitters changes on insulin secretion. Our analysis of the dynamic data provides support for the hypothesis that activation of Ca2+-dependent adenylyl cyclases play a critical role in modulating the effects of glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and catecholamines. ..."
Reference:
1 . Fridlyand LE, Philipson LH (2016) Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis. PLoS One 11:e0152869 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Human;
Cell Type(s):
Channel(s): Ca pump; ATP-senstive potassium current;
Gap Junctions:
Receptor(s): Adrenergic; Muscarinic; IP3; M3; Cholinergic Receptors;
Gene(s):
Transmitter(s): Acetylcholine; Norephinephrine; Ephinephrine; Ions;
Simulation Environment: MATLAB;
Model Concept(s): Calcium dynamics; Electrical-chemical; G-protein coupled; Ion Channel Kinetics;
Implementer(s): Althaf, Athil A Z ; Mishra, Urvi ; Konnur, Seeraja [seeraja.dsa at gmail.com];
Search NeuronDB for information about:  M3; Muscarinic; Adrenergic; Cholinergic Receptors; IP3; ATP-senstive potassium current; Ca pump; Acetylcholine; Ephinephrine; Norephinephrine; Ions;
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FridlyandPhilipson2016matlab
readme.txt
final_code.m
                            
The purpose of our study was to implement the published model of

Fridlyand LE, Philipson LH (2016) Pancreatic Beta Cell G-Protein
Coupled Receptors and Second Messenger Interactions: A Systems Biology
Computational Analysis. PLoS One 11:e0152869
http://dx.doi.org/10.1371/journal.pone.0152869

on MATLAB. We were interested in modeling the insulin secreting
pancreatic beta cell environment which includes membrane mechanisms, G
protein coupled receptor mechanisms, cAMP and PLC pathway and
cytosolic and endoplasmic reticulum calcium dynamics.

To run the code

The code is written in matlab. There are 3 sections in this code and
all together there are 43 graphs.  All graphs are not needed at the
same time. So for simplicity we have commented all the graphs and the
user should remove the comments as desired. To run, open matlab and
for example, type

final_code

on the matlab command prompt.