" ... Here, we incorporate newly revealed subgroups of neurons
within the GPe into an existing computational model of the basal
ganglia, and investigate their role in action selection. Three
main results ensued. First, using previously used metrics for
selection, the new extended connectivity improved the action
selection performance of the model. Second, low frequency theta
oscillations were observed in the subpopulation of the GPe (the
TA or ‘arkypallidal’ neurons) which project exclusively to the
striatum. These oscillations were suppressed by increased
dopamine activity — revealing a possible link with symptoms of
Parkinson’s disease. Third, a new phenomenon was observed in
which the usual monotonic relationship between input to the basal
ganglia and its output within an action ‘channel’ was, under some
circumstances, reversed.
..."
Reference:
1 .
Suryanarayana SM, Hellgren Kotaleski J, Grillner S, Gurney KN (2019) Roles for globus pallidus externa revealed in a computational model of action selection in the basal ganglia. Neural Netw 109:113-136 [PubMed]
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