This the readme for the model code associated with the paper:
Mäki-Marttunen T, Devor A, Phillips WA, Dale AM, Andreassen OA,
Einevoll GT (2019) Computational modeling of genetic contributions to
excitability and neural coding in layer V pyramidal cells:
applications to schizophrenia pathology Front. Comput. Neurosci.
This code was contributed by T Mäki-Marttunen.
HOC-commands for simulations based on (Hay et al. 2011, "Models of
neocortical layer 5b pyramidal cells capturing a wide range of
dendritic and perisomatic active properties", PLoS Comp Biol. 2011
HOC-commands for in-vivo-like synaptic inputs based on (Hay & Segev
2015, "Dendritic excitability and gain control in recurrent cortical
microcircuits", Cerebral Cortex 25(10): 3561-3571)
Library of variants based on (Maki-Marttunen et al. 2016, "Functional
Effects of Schizophrenia-Linked Genetic Variants on Intrinsic
Single-Neuron Excitability: A Modeling Study", Biol Psychiatry Cogn
Neurosci Neuroimaging. 2016 Jan 1;1(1):49-59), see also
(Maki-Marttunen et al. 2017, "Pleiotropic effects of
schizophrenia-associated genetic variants in neuron firing and cardiac
pacemaking revealed by computational modeling", Translational
Psychiatryvolume 7, Article number: 5 (2017))
Please see the readme's in the almog and hay folders for how to run.
2022-05: Updated MOD files to contain valid C++ and be compatible with
the upcoming versions 8.2 and 9.0 of NEURON.