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Criticality,degeneracy in injury-induced changes in primary afferent excitability (Ratte et al 2014)
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"Neuropathic pain remains notoriously difficult to treat despite numerous drug targets. Here, we offer a novel explanation for this intractability. Computer simulations predicted that qualitative changes in primary afferent excitability linked to neuropathic pain arise through a switch in spike initiation dynamics when molecular pathologies reach a tipping point (criticality), and that this tipping point can be reached via several different molecular pathologies (degeneracy). ..."
Ratté S, Zhu Y, Lee KY, Prescott SA (2014) Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain.
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Neuron or other electrically excitable cell;
Abstract Morris-Lecar neuron;
Dorsal Root Ganglion (DRG) cell;
Action Potential Initiation;
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