Dynamical patterns underlying response properties of cortical circuits (Keane et al 2018)


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Accession:257631
"Recent experimental studies show cortical circuit responses to external stimuli display varied dynamical properties. These include stimulus strength-dependent population response patterns, a shift from synchronous to asynchronous states and a decline in neural variability. To elucidate the mechanisms underlying these response properties and explore how they are mechanistically related, we develop a neural circuit model that incorporates two essential features widely observed in the cerebral cortex. The first feature is a balance between excitatory and inhibitory inputs to individual neurons; the second feature is distance-dependent connectivity. We show that applying a weak external stimulus to the model evokes a wave pattern propagating along lateral connections, but a strong external stimulus triggers a localized pattern; these stimulus strength-dependent population response patterns are quantitatively comparable with those measured in experimental studies. ..."
Reference:
1 . Keane A, Henderson JA, Gong P (2018) Dynamical patterns underlying response properties of cortical circuits. J R Soc Interface [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Abstract integrate-and-fire leaky neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: C or C++ program (web link to model);
Model Concept(s): Activity Patterns;
Implementer(s): Keane, Adam ; Gong, Pulin [pulin.gong at sydney.edu.au];
(located via links below)