Phenomenological models of NaV1.5: Hodgkin-Huxley and kinetic formalisms (Andreozzi et al 2019)

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"Computational models of ion channels represent the building blocks of conductance-based, biologically inspired models of neurons and neural networks. Ion channels are still widely modelled by means of the formalism developed by the seminal work of Hodgkin and Huxley (HH), although the electrophysiological features of the channels are currently known to be better fitted by means of kinetic Markov-type models. The present study is aimed at showing why simplified Markov-type kinetic models are more suitable for ion channels modelling as compared to HH ones, and how a manual optimization process can be rationally carried out for both. ..."
1 . Andreozzi E, Carannante I, D'Addio G, Cesarelli M, Balbi P (2019) Phenomenological models of NaV1.5. A side by side, procedural, hands-on comparison between Hodgkin-Huxley and kinetic formalisms Scientific Reports 9:17493 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Sodium;
Gap Junctions:
Gene(s): Nav1.5 SCN5A;
Simulation Environment: NEURON; Python;
Model Concept(s): Markov-type model;
Implementer(s): Carannante, Ilaria [ilariac at]; Balbi, Pietro [piero.balbi at]; Andreozzi, Emilio [emilio.andreozzi at];
Search NeuronDB for information about:  I Sodium;
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