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CA1 pyramidal neuron: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
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Model Information
Model File
Accession:
258867
The study shows that IPSCs mediated by a5-subunit containing GABAA receptors are strongly outward-rectifying generating 4-fold larger conductances above -50?mV than at rest. Experiments and modeling show that synaptic activation of these receptors can very effectively control voltage-dependent NMDA-receptor activation in a spatiotemporally controlled manner in fine dendrites of CA1 pyramidal cells. The files contain the NEURON code for Fig.8, Fig.S8 and Fig.S9 of the paper. The model is based on the model published by Bloss et al., 2017. Physiological properties of GABA synapses were modified as determined by optogenetic activation of inputs during voltage-clamp recordings in Schulz et al. 2018. Other changes include stochastic synaptic release and short-term synaptic plasticity. All changes of mechanisms and parameters are detailed in the Methods of the paper. Simulation can be run by starting start_simulation.hoc after running mknrndll. The files that model the individual figures have to be uncommented in start_simulation.hoc beforehand.
Reference:
1 .
Schulz JM, Knoflach F, Hernandez MC, Bischofberger J (2018) Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear a5-GABAA receptors.
Nat Commun
9
:3576
[
PubMed
]
Citations
Citation Browser
Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Dendrite;
Synapse;
Brain Region(s)/Organism:
Hippocampus;
Mouse;
Cell Type(s):
Hippocampus CA1 pyramidal GLU cell;
Channel(s):
I h;
I A;
Gap Junctions:
Receptor(s):
GabaA;
GabaB;
AMPA;
NMDA;
Gene(s):
Transmitter(s):
Gaba;
Glutamate;
Simulation Environment:
NEURON;
Model Concept(s):
Implementer(s):
Schulz, Jan M [j.schulz at unibas.ch];
Search NeuronDB
for information about:
Hippocampus CA1 pyramidal GLU cell
;
GabaA
;
GabaB
;
AMPA
;
NMDA
;
I A
;
I h
;
Gaba
;
Glutamate
;
Download the displayed file
/
Alpha5_NMDA_CA1_pyr
README.html
dists.mod
*
Other models using dists.mod:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
eff.mod
*
Other models using eff.mod:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
exc.mod
*
Other models using exc.mod:
Single compartment: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
gabab.mod
h.mod
id.mod
*
Other models using id.mod:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
inh.mod
kad.mod
*
Other models using kad.mod:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
kap.mod
*
Other models using kap.mod:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
kdr.mod
*
Other models using kdr.mod:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
na3.mod
*
Other models using na3.mod:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
nmdaSyn.mod
syns.mod
*
Other models using syns.mod:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
tonic.mod
activateExcitation.hoc
activateInhibition_JMS.hoc
addChannels_JMS.hoc
addExcitation_JMS.hoc
addVgatInhibition_JMS.hoc
channelParameters.hoc
Connect_Stimulator2ExcSyn.hoc
Connect_Stimulator2InhSyn.hoc
Fig8_tuft_NMDA_spike.hoc
FigS8_SR_SLM_burst_stim.hoc
FigS9_test_TI.hoc
flagVgatInhibition_JMS.hoc
Generate_Stimulator.hoc
getBranchOrder.hoc
*
Other models using getBranchOrder.hoc:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
idMorph.hoc
inhibitionBiophysics_JMS.hoc
initializationAndRun.hoc
*
Other models using initializationAndRun.hoc:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
Single compartment: nonlinear a5-GABAAR controls synaptic NMDAR activation (Schulz et al 2018)
loadMorph.hoc
*
Other models using loadMorph.hoc:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
mosinit.hoc
naceaxon.nrn
*
Other models using naceaxon.nrn:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
Distance-dependent synaptic strength in CA1 pyramidal neurons (Menon et al. 2013)
Print-to-File.hoc
processMorph.hoc
*
Other models using processMorph.hoc:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
proofreadMorph.hoc
*
Other models using proofreadMorph.hoc:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
resetNSeg.hoc
*
Other models using resetNSeg.hoc:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
screenshot.png
start_simulation.hoc
synHelperScripts.hoc
SynStim_SR_SLM_control.hoc
SynStim_SR_SLM_noInh.hoc
SynStim_SR_SLM_redInh.hoc
SynStim_SR_SLM_TI.hoc
tuft_NMDA_spike_fast.hoc
tuft_NMDA_spike_noRect.hoc
twinApical.swc
*
Other models using twinApical.swc:
CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)
Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites (Bloss et al 2018)
update_Synapses.hoc
NEURON { SUFFIX eff RANGE L,d,x } ASSIGNED { L d x }
