Respiratory central pattern generator including Kolliker-Fuse nucleus (Wittman et al 2019)

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Accession:259786
We present three highly reduced conductance-based models for the core of the respiratory CPG. All successfully simulate respiratory outputs across eupnoeic and vagotomized conditions and show that loss of inhibition to the pontine Kolliker-Fuse nucleus reproduces the key respiratory alterations associated with Rett syndrome.
Reference:
1 . Wittman S, Abdala AP, Rubin JE (2019) Reduced computational modelling of K├Âlliker-Fuse contributions to breathing patterns in Rett syndrome. J Physiol 597:2651-2672 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Brainstem;
Cell Type(s):
Channel(s): I Na,p;
Gap Junctions:
Receptor(s): AMPA; GabaA; Glycine;
Gene(s):
Transmitter(s): Glutamate; Gaba; Glycine;
Simulation Environment: XPP; MATLAB;
Model Concept(s): Respiratory control;
Implementer(s): Wittman, Samuel [swittman52 at gmail.com];
Search NeuronDB for information about:  GabaA; AMPA; Glycine; I Na,p; Glycine; Gaba; Glutamate;