Robust and tunable bursting requires slow positive feedback (Franci et al 2018)


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Accession:260596
"We highlight that the robustness and tunability of a bursting model critically rely on currents that provide slow positive feedback to the membrane potential. Such currents have the ability to make the total conductance of the circuit negative in a timescale that is termed “slow” because it is intermediate between the fast timescale of the spike upstroke and the ultraslow timescale of even slower adaptation currents. We discuss how such currents can be assessed either in voltage-clamp experiments or in computational models. We show that, while frequent in the literature, mathematical and computational models of bursting that lack the slow negative conductance are fragile and rigid. Our results suggest that modeling the slow negative conductance of cellular models is important when studying the neuromodulation of rhythmic circuits at any broader scale."
Reference:
1 . Franci A, Drion G, Sepulchre R (2018) Robust and tunable bursting requires slow positive feedback. J Neurophysiol 119:1222-1234 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I K,Ca; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: Julia (web link to model);
Model Concept(s): Bursting; Temporal Pattern Generation; Bifurcation;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I L high threshold; I T low threshold; I A; I K; I K,Ca; I Potassium;
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