Tonic activation of extrasynaptic NMDA-R promotes bistability (Gall & Dupont 2020)

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Accession:261709
Our theoretical model provides a simple description of neuronal electrical activity that takes into account the tonic activity of extrasynaptic NMDA receptors and a cytosolic calcium compartment. We show that calcium influx mediated by the tonic activity of NMDA-R can be coupled directly to the activation of calcium-activated potassium channels, resulting in an overall inhibitory effect on neuronal excitability. Furthermore, the presence of tonic NMDA-R activity promotes bistability in electrical activity by dramatically increasing the stimulus interval where both a stable steady state and repetitive firing can coexist. These results could provide an intrinsic mechanism for the constitution of memory traces in neuronal circuits.
Reference:
1 . Gall D, Dupont G (2019) Tonic Activation of Extrasynaptic NMDA Receptors Decreases Intrinsic Excitability and Promotes Bistability in a Model of Neuronal Activity. Int J Mol Sci [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum interneuron granule GLU cell;
Channel(s): I Calcium; I K,Ca; I Sodium; I K;
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: FORTRAN;
Model Concept(s): Memory; Action Potential Initiation; Calcium dynamics; Aging/Alzheimer`s;
Implementer(s): Gall, David ; Dupont, Geneviève ;
Search NeuronDB for information about:  Cerebellum interneuron granule GLU cell; NMDA; I K; I K,Ca; I Sodium; I Calcium; Glutamate;