Survey of electrically evoked responses in the retina (Tsai et al 2017)

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Accession:262389
"Cones and horizontal cells are interconnected to adjacent cones and horizontal cells, respectively, with gap junctions. In particular, the horizontal cell gap junctional conductance is modulated by exogenous factors. What roles does this conductance play in the electrically evoked responses of horizontal cells? To address this question, we constructed a computational model consisting of the cone and horizontal cell layer..."
Reference:
1 . Tsai D, Morley JW, Suaning GJ, Lovell NH (2017) Survey of electrically evoked responses in the retina - stimulus preferences and oscillation among neurons. Sci Rep 7:13802 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Extracellular;
Brain Region(s)/Organism: Retina;
Cell Type(s): Retina photoreceptor cone GLU cell; Retina horizontal cell;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Oscillations;
Implementer(s): Tsai, David [d.tsai at unsw.edu.au];
Search NeuronDB for information about:  Retina photoreceptor cone GLU cell;
USAGE
    1   run Make to compile the MOD files

    2.1 To start network model simulation, run nrngui with:
        $ nrngui init-ConeHz.hoc
        $ nrngui init-Hz.hoc

    2.2 To start E-I pair simulation, run nrngui with:
        $ nrngui exp-PairCellConeCone.hoc
        $ nrngui exp-PairCellHzHz.hoc


FILE SUMMARY
    *.ses                       Session files for setting up the UI
    *.mod                       Model mechanism implementation files

    Cone.hoc                    Cone template file
    ConeTester.hoc              For testing cones individually
    HzCell.hoc                  Horizontal cell template file
    HzCellTester.hoc            For testing horizontal cells individually

    exp-2cellsSyn.hoc           For testing synaptic mechanisms
    exp-CellPair.hoc            Common denominator for testing cell-pairs synapses
    exp-CellPairConeCone.hoc    Simulation of cone cone E-I pair 
    exp-CellPairHzHz.hoc        Simulation of hz hz E-I pair

    init-ConeHz.hoc             Simulation of a horizontal cell network model
    init-Hz.hoc                 Simulation of a cone horizontal cell network model
    network.hoc                 Common denominator for the network model

    util.hoc                    Misc convenience procedures