Mean field model for Hodgkin Huxley networks of neurons (Carlu et al 2020)

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Accession:263259
"We present a mean-field formalism able to predict the collective dynamics of large networks of conductance-based interacting spiking neurons. We apply this formalism to several neuronal models, from the simplest Adaptive Exponential Integrate-and-Fire model to the more complex Hodgkin-Huxley and Morris-Lecar models. We show that the resulting mean-field models are capable of predicting the correct spontaneous activity of both excitatory and inhibitory neurons in asynchronous irregular regimes, typical of cortical dynamics. Moreover, it is possible to quantitatively predict the population response to external stimuli in the form of external spike trains. This mean-field formalism therefore provides a paradigm to bridge the scale between population dynamics and the microscopic complexity of the individual cells physiology."
Reference:
1 . Carlu M, Chehab O, Dalla Porta L, Depannemaecker D, Héricé C, Jedynak M, Köksal Ersöz E, Muratore P, Souihel S, Capone C, Zerlaut Y, Destexhe A, di Volo M (2020) A mean-field approach to the dynamics of networks of complex neurons, from nonlinear Integrate-and-Fire to Hodgkin-Huxley models. J Neurophysiol 123:1042-1051 [PubMed]
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Brain Region(s)/Organism:
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Simulation Environment: Python;
Model Concept(s): Methods;
Implementer(s): di Volo, Matteo [matteo.di-volo at cyu.fr];
 
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