Hippocampal pyramidal neurons are thought to encode spatial information. A subset of these cells, named place cells, are active only when the animal traverses a specific region within the environment. Although vastly studied experimentally, the development and stabilization of place fields are not fully understood. Here, we propose a mechanistic model of place cell formation in the hippocampal CA1 region. Using our model, we reproduce place field dynamics observed experimentally and provide a mechanistic explanation for the stabilization of place fields. Finally, our model provides specific predictions on protocols to shift place field location.
Pedrosa V, Clopath C (2020) The interplay between somatic and dendritic inhibition promotes the emergence and stabilization of place fields. PLoS Comput Biol 16:e1007955 [PubMed]