Interplay between somatic and dendritic inhibition promotes place fields (Pedrosa & Clopath 2020)

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Accession:266535
Hippocampal pyramidal neurons are thought to encode spatial information. A subset of these cells, named place cells, are active only when the animal traverses a specific region within the environment. Although vastly studied experimentally, the development and stabilization of place fields are not fully understood. Here, we propose a mechanistic model of place cell formation in the hippocampal CA1 region. Using our model, we reproduce place field dynamics observed experimentally and provide a mechanistic explanation for the stabilization of place fields. Finally, our model provides specific predictions on protocols to shift place field location.
Reference:
1 . Pedrosa V, Clopath C (2020) The interplay between somatic and dendritic inhibition promotes the emergence and stabilization of place fields. PLoS Comput Biol 16:e1007955 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Connectionist Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Abstract rate-based neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: Python;
Model Concept(s): Place cell/field; Synaptic Plasticity;
Implementer(s): Pedrosa, Victor [v.pedrosa15 at imperial.ac.uk];