Phasic ACh promotes gamma oscillations in E-I networks (Lu et al, 2020)

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In a biophysically-based model, we show that a network of excitatory (E) and inhibitory (I) neurons that initially displays asynchronous firing can generate transient gamma oscillatory activity in response to simulated brief pulses of ACh. ACh effects are simulated as transient modulation of the conductance of an M-type K+ current which is blocked by activation of muscarinic receptors and has significant effects on neuronal excitability. The ACh-induced effects on the M current conductance, gks, change network dynamics to promote the emergence of network gamma rhythmicity through a Pyramidal-Interneuronal Network Gamma (PING) mechanism.
1 . Lu Y, Sarter M, Zochowski M, Booth V (2020) Phasic cholinergic signaling promotes emergence of local gamma rhythms in excitatory-inhibitory networks. Eur J Neurosci 52:3545-3560 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Prefrontal cortex (PFC);
Cell Type(s):
Channel(s): I Potassium; I M;
Gap Junctions:
Receptor(s): Muscarinic;
Transmitter(s): Acetylcholine;
Simulation Environment: MATLAB;
Model Concept(s): Oscillations; Gamma oscillations;
Search NeuronDB for information about:  Muscarinic; I M; I Potassium; Acetylcholine;
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