Find models by
Find models for
Find models of
Phasic ACh promotes gamma oscillations in E-I networks (Lu et al, 2020)
Download zip file
Help downloading and running models
In a biophysically-based model, we show that a network of excitatory (E) and inhibitory (I) neurons that initially displays asynchronous firing can generate transient gamma oscillatory activity in response to simulated brief pulses of ACh. ACh effects are simulated as transient modulation of the conductance of an M-type K+ current which is blocked by activation of muscarinic receptors and has significant effects on neuronal excitability. The ACh-induced effects on the M current conductance, gks, change network dynamics to promote the emergence of network gamma rhythmicity through a Pyramidal-Interneuronal Network Gamma (PING) mechanism.
Lu Y, Sarter M, Zochowski M, Booth V (2020) Phasic cholinergic signaling promotes emergence of local gamma rhythms in excitatory-inhibitory networks.
Eur J Neurosci
(Click on a link to find other models with that property)
Prefrontal cortex (PFC);
for information about:
File not selected
<- Select file from this column.