A model of ASIC1a and synaptic cleft pH modulating wind-up in wide dynamic range neurons (Delrocq)

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Accession:267666
We introduce a model of ASIC1a homomeric (and heteromeric) ion channel inserted into a pre-existing model of wide dynamic range (WDR) neuron of the spinal cord together with a novel synaptic cleft acidification mechanism. This computational model shows a dual contribution of the ASIC1a channels to wind-up, a facilitation mechanism of WDR neurons, which has been verified experimentally: inhibiting or maximally activating ASICs reduce wind-up. The wind-up inhibition by activation of ASICs is likely mediated by calcium influx and calcium-activated potassium channels.
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor; Synapse; Neuron or other electrically excitable cell; Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Wide dynamic range neuron;
Channel(s): I Calcium; I Potassium; I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Facilitation; Detailed Neuronal Models; Ion Channel Kinetics; Pain processing;
Implementer(s):
Search NeuronDB for information about:  I Sodium; I Calcium; I Potassium; 
load_file("nrngui.hoc")
// load_file("wdr-complete-model.hoc")   //4.A
// load_file("wdr-complete-model-without-interneuron.hoc")   //4.B


load_file("wdr-complete-model-without-interneuron.hoc")
cvode.active(1)
cvode.use_local_dt(1)
cvode.atol(1e-4)

// set_noise(0.0001, 0.0001)  // default
// n_stim_sets = 16     // then needs to construct stim times

run()

store_wdr("mitx.dat")