A biologically-detailed model of the mammalian olfactory bulb, incorporating
the mitral and granule cells and the dendrodendritic synapses between them.
The results of simulation experiments with electrical stimulation agree
closely in most details with published experimental data. The model predicts
that the time course of dendrodendritic inhibition is dependent on the
network connectivity as well as on the intrinsic parameters of the synapses.
In response to simulated odor stimulation, strongly activated mitral cells
tend to suppress neighboring cells, the mitral cells readily synchronize
their firing, and increasing the stimulus intensity increases the degree of
synchronization. For more details, see the reference below.
Davison AP, Feng J, Brown D (2003) Dendrodendritic inhibition and simulated odor responses in a detailed olfactory bulb network model. J Neurophysiol 90:1921-35 [PubMed]