Short term plasticity of synapses onto V1 layer 2/3 pyramidal neuron (Varela et al 1997)

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Accession:3264
This archive contains 3 mod files for NEURON that implement the short term synaptic plasticity model described in Varela, J.A., Sen, K., Gibson, J., Fost, J., Abbott, L.R., and Nelson, S.B.. A quantitative description of short-term plasticity at excitatory synapses in layer 2/3 of rat primary visual cortex. Journal of Neuroscience 17:7926-7940, 1997. Contact ted.carnevale@yale.edu if you have questions about this implementation of the model.
Reference:
1 . Varela JA, Sen K, Gibson J, Fost J, Abbott LF, Nelson SB (1997) A quantitative description of short-term plasticity at excitatory synapses in layer 2/3 of rat primary visual cortex. J Neurosci 17:7926-40 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Plasticity; Short-term Synaptic Plasticity; Facilitation; Depression; Vision;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu];
Search NeuronDB for information about:  Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell; AMPA; I Na,t; I K; Glutamate;
load_file("nrngui.hoc")
load_file("cell2.ses")
load_file("stimf3d.ses")
load_file("netf3d.ses")
load_file("guif3d.ses")

objref vbox
vbox = new VBox()
vbox.intercept(1)       //all following creations go into the "vbox" box
xpanel("Instructions")
xlabel("Fig. 3D using fast epsp.")
xlabel("Presynaptic Pre1 makes an excitatory projection to postsynaptic Cell0.")
xlabel("Soma of postsynaptic cell is voltage clamped at -65mV.")
xlabel("Graphs show Vm at soma, synaptic conductance, and clamp current.")
xlabel("For fastest results, turn on 'Quiet' in the RunControl window.")
xpanel()
vbox.intercept(0)       //ends intercept mode 
vbox.map()              //draw the box and its contents