Short term plasticity of synapses onto V1 layer 2/3 pyramidal neuron (Varela et al 1997)

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Accession:3264
This archive contains 3 mod files for NEURON that implement the short term synaptic plasticity model described in Varela, J.A., Sen, K., Gibson, J., Fost, J., Abbott, L.R., and Nelson, S.B.. A quantitative description of short-term plasticity at excitatory synapses in layer 2/3 of rat primary visual cortex. Journal of Neuroscience 17:7926-7940, 1997. Contact ted.carnevale@yale.edu if you have questions about this implementation of the model.
Reference:
1 . Varela JA, Sen K, Gibson J, Fost J, Abbott LF, Nelson SB (1997) A quantitative description of short-term plasticity at excitatory synapses in layer 2/3 of rat primary visual cortex. J Neurosci 17:7926-40 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L2/3 pyramidal GLU cell;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Plasticity; Short-term Synaptic Plasticity; Facilitation; Depression; Vision;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu];
Search NeuronDB for information about:  Neocortex L2/3 pyramidal GLU cell; AMPA; I Na,t; I K; Glutamate;
load_file("nrngui.hoc")

objref menubox

proc run_fig3a() {
	load_file("initf3a.hoc")
	menubox.unmap()
}

proc run_fig3c() {
	load_file("initf3c.hoc")
	menubox.unmap()
}

proc run_fig3d() {
	load_file("initf3d.hoc")
	menubox.unmap()
}

proc run_fig3e() {
	load_file("initf3e.hoc")
	menubox.unmap()
}

proc run_art() {
	load_file("initart.hoc")
	menubox.unmap()
}

proc run_cel() {
	load_file("initcel.hoc")
	menubox.unmap()
}

proc run_cel2() {
	load_file("initcel2.hoc")
	menubox.unmap()
}

proc run_test() {
	load_file("inittest.hoc")
	menubox.unmap()
}

proc make_demopanel() {
	menubox = new VBox()
	menubox.intercept(1)       //all following creations go into the "vbox" box
	xpanel("Short-term synaptic plasticity")
	xlabel("Models of short-term synaptic plasticity")
	xlabel("Choose one of the following:")
	xbutton("Fig. 3A using slow epsp", "run_fig3a()")
	xbutton("Fig. 3C using slow epsp", "run_fig3c()")
	xbutton("Fig. 3D using fast epsp", "run_fig3d()")
	xbutton("Fig. 3E", "run_fig3e()")
	xlabel("Other demos just for fun:")
	xbutton("Artificial (integrate and fire) cell", "run_art()")
	xbutton("'Biophysical' cell with fast epsp", "run_cel()")
	xbutton("'Biophysical' cell with slow epsp", "run_cel2()")
	xbutton("'Biophysical' cell with multiple input streams", "run_test()")
	xpanel()
	menubox.intercept(0)       //ends intercept mode
	menubox.map()              //draw the box and its contents
}

make_demopanel()