Short term plasticity of synapses onto V1 layer 2/3 pyramidal neuron (Varela et al 1997)

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Accession:3264
This archive contains 3 mod files for NEURON that implement the short term synaptic plasticity model described in Varela, J.A., Sen, K., Gibson, J., Fost, J., Abbott, L.R., and Nelson, S.B.. A quantitative description of short-term plasticity at excitatory synapses in layer 2/3 of rat primary visual cortex. Journal of Neuroscience 17:7926-7940, 1997. Contact ted.carnevale@yale.edu if you have questions about this implementation of the model.
Reference:
1 . Varela JA, Sen K, Gibson J, Fost J, Abbott LF, Nelson SB (1997) A quantitative description of short-term plasticity at excitatory synapses in layer 2/3 of rat primary visual cortex. J Neurosci 17:7926-40 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Plasticity; Short-term Synaptic Plasticity; Facilitation; Depression; Vision;
Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu];
Search NeuronDB for information about:  Neocortex V1 L2/6 pyramidal intratelencephalic GLU cell; AMPA; I Na,t; I K; Glutamate;
objectvar save_window_, rvp_
objectvar scene_vector_[6]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}

//Begin ArtCellGUI[0]
{
load_file("netbild.hoc")
}
ocbox_ = new ArtCellGUI(1)
{object_push(ocbox_)}
{
tobj = new MechanismStandard("NetStim")
tobj.set("interval", 100, 0)
tobj.set("number", 200, 0)
tobj.set("start", 10, 0)
tobj.set("noise", 0, 0)
}
{append(tobj, "Sfast")}
{
tobj = new MechanismStandard("NetStim")
tobj.set("interval", 200, 0)
tobj.set("number", 200, 0)
tobj.set("start", 10, 0)
tobj.set("noise", 0, 0)
}
{append(tobj, "Sslow")}
{object_pop()}
{
ocbox_.map("ArtCellGUI[0]", 0, 466, 449.28, 291.84)
}
objref ocbox_
//End ArtCellGUI[0]

{WindowMenu[0].ses_gid(1, 0, 0, "netstuff")}

//Begin NetReadyCellGUI[0]
{
load_file("netbild.hoc")
}
{ocbox_ = new NetReadyCellGUI(1)}
{object_push(ocbox_)}
{tobj = new CellBuild(1)}
{object_push(tobj)}
{
version(1)
continuous = 0
}
{object_push(topol)}
{
first = 0
slist.remove_all()
sname = "dend"
objref tobj
}
{
tobj = new CellBuildSection("soma",0, 0, tobj, 0) slist.append(tobj)
  tobj.position(0,0,15,0) tobj.lx=7.5 tobj.ly=0 tobj.i3d=0
}
for i=0, slist.count-1 {slist.object(i).rdses()}
{object_pop()}
{
}
{object_push(subsets)}
{first = 0}
{tobj = new SNList("all") snlist.append(tobj)}
for i=0,0 tobj.add(bild.topol.slist.object(fscan()))
0
{object_pop()}
{
}
{object_push(geom)}
{
first = 0
tobj = new GeoSpec(2)
tobj.value = 100
bild.subsets.snlist.object(0).geo.append(tobj)
set_default()
}
{object_pop()}
{
{
save_window_=geom.g
save_window_.size(-200,200,-150,150)
geom.g = save_window_
save_window_.save_name("geom.g")
}
}
{object_push(memb)}
{first=0}
{
tobj = new GeoSpec(0)
tobj.value = 80
tobj.set_default()
tobj = new MStanWrap(tobj, 0)
bild.subsets.snlist.object(0).ml.append(tobj)
}
{
tobj = new GeoSpec(1)
tobj.value = 1
tobj.set_default()
tobj = new MStanWrap(tobj, 0)
bild.subsets.snlist.object(0).ml.append(tobj)
}
{
tobj = new MechanismStandard("pas")
tobj.set("g_pas", 5e-05, 0)
tobj.set("e_pas", -70, 0)
tobj = new MStanWrap(tobj, 1)
bild.subsets.snlist.object(0).ml.append(tobj)
}
{object_pop()}
{
}
{object_push(manage)}
{
first = 0
classname = "Cell"
etop=1 esub=1 egeom=1 emem=1
itop=1 isub=0 igeom=0 imem=0
bild.topol.names_off = 0
bild.topol.circles_off = 0
}
{object_pop()}
{
cexport()
}
{
save_window_=gtopol
save_window_.size(-200,200,-150,150)
gtopol = save_window_
save_window_.save_name("gtopol")
}
{object_pop()}
stgui = new SynTypeGUI(1)
{object_push(stgui)}
{
tobj = new MechanismStandard("FDSExp2Syn")
tobj.set("tau1", 1, 0)
tobj.set("tau2", 2, 0)
tobj.set("e", 0, 0)
tobj.set("f", 0.917, 0)
tobj.set("tau_F", 94, 0)
tobj.set("d1", 0.416, 0)
tobj.set("tau_D1", 380, 0)
tobj.set("d2", 0.975, 0)
tobj.set("tau_D2", 9200, 0)
}
{append(tobj, "Ea")}
{
tobj = new MechanismStandard("FDSExp2Syn")
tobj.set("tau1", 1, 0)
tobj.set("tau2", 2, 0)
tobj.set("e", 0, 0)
tobj.set("f", 0.917, 0)
tobj.set("tau_F", 94, 0)
tobj.set("d1", 0.416, 0)
tobj.set("tau_D1", 380, 0)
tobj.set("d2", 0.975, 0)
tobj.set("tau_D2", 9200, 0)
}
{append(tobj, "Eb")}
{
tobj = new MechanismStandard("FDSExp2Syn")
tobj.set("tau1", 1, 0)
tobj.set("tau2", 2, 0)
tobj.set("e", 0, 0)
tobj.set("f", 0.917, 0)
tobj.set("tau_F", 94, 0)
tobj.set("d1", 0.416, 0)
tobj.set("tau_D1", 380, 0)
tobj.set("d2", 0.975, 0)
tobj.set("tau_D2", 9200, 0)
}
{append(tobj, "Eab")}
{object_pop()}
nrc = new NetReadyCell(tobj, stgui.stypelist)
nrc.name = "C"
tobj = nrc.cb.topol.slist.object(0)
{nrc.synlist.append(new SynTypeInstance(nrc.stype.object[0],tobj,0.5,0.5,-1))}
tobj = nrc.cb.topol.slist.object(0)
{nrc.synlist.append(new SynTypeInstance(nrc.stype.object[1],tobj,0.5,0.5,2))}
tobj = nrc.cb.topol.slist.object(0)
{nrc.synlist.append(new SynTypeInstance(nrc.stype.object[2],tobj,0.5,0.5,3))}
{g.size(-166.875,166.875,-125.208,125.208)}
{object_pop()}
{
ocbox_.map("NetReadyCellGUI[0]", 0, 61, 404.16, 361.92)
}
objref ocbox_
//End NetReadyCellGUI[0]

{WindowMenu[0].ses_gid(0, 0, 0, "netstuff")}

//Begin NetGUI[0]
{
load_file("netbild.hoc")
}
{ocbox_ = new NetGUI(1)}
{object_push(ocbox_)}
{mapold2new = new Vector()  missing = new List()}
original_type("C")
original_type("Sfast")
original_type("Sslow")
newnode(0, -62, 35)
newnode(1, -126, 37)
newnode(2, 10, 36)
newedge(1, 0, 0, 0.0001, 1)
newedge(1, 0, 2, 0.0001, 1)
newedge(2, 0, 1, 0.0001, 51)
newedge(2, 0, 2, 0.0001, 51)
// fix for 5.0.1
// create1()
{create_ = 1  create1()}
{g.size(-166.667,166.667,-124.997,124.997)}
{object_pop()}
{
ocbox_.map("NetGUI[0]", 0, 649, 528, 327.36)
}
objref ocbox_
//End NetGUI[0]

{WindowMenu[0].ses_gid(0, 0, 0, "netstuff")}
objectvar scene_vector_[1]
{doNotify()}