Thalamocortical and Thalamic Reticular Network (Destexhe et al 1996)

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Accession:3343
NEURON model of oscillations in networks of thalamocortical and thalamic reticular neurons in the ferret. (more applications for a model quantitatively identical to previous DLGN model; updated for NEURON v4 and above)
Reference:
1 . Destexhe A, Bal T, McCormick DA, Sejnowski TJ (1996) Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices. J Neurophysiol 76:2049-70 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell;
Channel(s): I Na,t; I T low threshold; I K,leak; I h;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Oscillations; Synchronization; Spatio-temporal Activity Patterns; Sleep; Calcium dynamics; Spindles;
Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; GabaA; GabaB; AMPA; I Na,t; I T low threshold; I K,leak; I h;
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DLGN_NEW
README
ampa.mod
cadecay.mod *
gabaa.mod
gabab.mod
HH2.mod *
Ih.mod *
IT.mod *
IT2.mod *
kleak.mod *
Fbic.oc
FbicL.oc
Fdelta.oc
FdeltaL.oc
Fspin.oc
FspinL.oc
mosinit.hoc *
RE.tem
rundemo.hoc
TC.tem
                            
/*--------------------------------------------------------------
	TEMPLATE FILE FOR DEFINING THALAMOCORTICAL NEURONS
	--------------------------------------------------

	One compartment model and currents derived from:

 	McCormick, D.A. and Huguenard, J.R.  A model of the 
	electrophysiological properties of thalamocortical relay neurons.  
	J. Neurophysiology 68: 1384-1400, 1992.

	- passive: parameters idem Rinzel
	- HH: Traub with higher threshold
	- IT: m2h, nernst, tau_h modified with double exponential
	- Ih: Huguenard with Ca++ dependence added, Ca++-binding protein
	- Ca++: simple decay, faster than McCormick


	This model is described in detail in:

	Destexhe, A., Bal, T., McCormick, D.A. and Sejnowski, T.J.
	Ionic mechanisms underlying synchronized oscillations and propagating
	waves in a model of ferret thalamic slices. Journal of Neurophysiology
	76: 2049-2070, 1996.
	See also http://www.cnl.salk.edu/~alain , http://cns.fmed.ulaval.ca


	Alain Destexhe, Salk Institute and Laval University, 1995

--------------------------------------------------------------*/


print " "
print " << defining template for one-compartment sTC cell >> "
print " "


begintemplate sTC		// create a new template object
public soma , kl

create soma[1]			// one compartment of about 29000 um2
soma {
  nseg = 1
  diam = 96
  L = 96
  cm = 1
}

objectvar kl

proc init() { local v_potassium, v_sodium

objectvar kl
kl = new kleak()


  v_potassium = -100		// potassium reversal potential 
  v_sodium = 50			// sodium reversal potential 

  soma {
	diam = 96		// geometry 
	L = 96			// so that area is about 29000 um2
	nseg = 1
	Ra = 100

	insert pas		// leak current 
	e_pas = -70		// from Rinzel
	g_pas = 1e-5

	kl.loc(0.5)		// K-leak
	Erev_kleak = v_potassium
	kl.gmax = 0.004		// (uS)
				// conversion: x(uS) = x(mS/cm2)*29000e-8*1e3
				//		     = x(mS/cm2) * 0.29


	insert hh2		// Hodgin-Huxley INa and IK 
	ek = v_potassium
	ena = v_sodium
	vtraub_hh2 = -25	// High threshold to simulated IA
	gnabar_hh2 = 0.09
	gkbar_hh2 = 0.01


	insert it		// T-current 
	cai = 2.4e-4 
	cao = 2 
	eca = 120 
	gcabar_it = 0.002


	insert iar		// h-current
	eh = -40		// reversal
	nca_iar = 4		// nb of binding sites for Ca++ on protein
	k2_iar = 0.0004		// decay of Ca++ binding on protein
	cac_iar = 0.002		// half-activation of Ca++ binding
	nexp_iar = 1		// nb of binding sites on Ih channel
	k4_iar = 0.001		// decay of protein binding on Ih channel
	Pc_iar = 0.01		// half-activation of binding on Ih channel
	ginc_iar = 2		// augm of conductance of bound Ih
	ghbar_iar = 2e-5	// low Ih for slow oscillations


	insert cad		// calcium decay
	depth_cad = 1
	taur_cad = 5
	cainf_cad = 2.4e-4
	kt_cad = 0		// no pump
  }

  print " "
  print "<< sTC: passive, Kleak, INa, IK, IT, Ih-CAM and Ca++ decay inserted >>"
  print " "

}
endtemplate sTC