Enhanced Excitability in Hermissenda: modulation by 5-HT (Cai et al 2003)

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Accession:34163
Serotonin (5-HT) applied to the exposed but otherwise intact nervous system results in enhanced excitability of Hermissenda type-B photoreceptors. Several ion currents in the type-B photoreceptors are modulated by 5-HT, including the A-type K+ current (IK,A), sustained Ca2+ current (ICa,S), Ca-dependent K+ current (IK,Ca), and a hyperpolarization-activated inward rectifier current (Ih). In this study,we developed a computational model that reproduces physiological characteristics of type B photoreceptors, e.g. resting membrane potential, dark-adapted spike activity, spike width, and the amplitude difference between somatic and axonal spikes. We then used the model to investigate the contribution of different ion currents modulated by 5-HT to the magnitudes of enhanced excitability produced by 5-HT. See paper for results and more details.
Reference:
1 . Cai Y, Baxter DA, Crow T (2003) Computational study of enhanced excitability in Hermissenda: membrane conductances modulated by 5-HT. J Comput Neurosci 15:105-21 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hermissenda photoreceptor Type B;
Channel(s): I Na,t; I L high threshold; I N; I A; I K; I h; I K,Ca; I Calcium; I A, slow;
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s): Serotonin;
Simulation Environment: SNNAP;
Model Concept(s): Activity Patterns; Action Potentials; Invertebrate;
Implementer(s): Cai, Yidao;
Search NeuronDB for information about:  I Na,t; I L high threshold; I N; I A; I K; I h; I K,Ca; I Calcium; I A, slow; Serotonin;
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Cai
readme.txt
00note.txt
axona.neu
axona2axonb.es
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axonc.neu
axonc2term.es
bph.ntw
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bph.ous
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bph.ous_vclamp
bph.ous2
bph.ous3
bph.ous4
bph.smu
bph.trt
bph.trt_casmod
bph.trt_Drmod
bph.trt_Iamod
bph.trt_Ihmod
bph.trt_Ikcamod
bph.trt_light
bph.trt_mixmod
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bph.trt_vclamp
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ca.A
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Ca.ion
ca.vdg *
Ca2Ikca.fBR
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design.txt
Dr.A
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Dr.vdg
exp.es
exp1.fnc
exp2.fnc
exp3.fnc
grf.def
Ia.A
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xcIkca.vdg *
xcIr.vdg
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xcNa.A *
xcNa.B *
xcNa.vdg *
                            
C:\nrnmodels\Cai\bph.smu
C:\nrnmodels\Cai\mv.neu
C:\nrnmodels\Cai\mvleak.vdg
C:\nrnmodels\Cai\soma.neu
C:\nrnmodels\Cai\Ikca.vdg
C:\nrnmodels\Cai\Ikca.A
C:\nrnmodels\Cai\Ikca.B
C:\nrnmodels\Cai\cat.vdg
C:\nrnmodels\Cai\cat.A
C:\nrnmodels\Cai\cat.B
C:\nrnmodels\Cai\Ir.vdg
C:\nrnmodels\Cai\Ir.A
C:\nrnmodels\Cai\Ia.vdg
C:\nrnmodels\Cai\Ia.A
C:\nrnmodels\Cai\Ia.B
C:\nrnmodels\Cai\Dr.vdg
C:\nrnmodels\Cai\Dr.A
C:\nrnmodels\Cai\Dr.B
C:\nrnmodels\Cai\ca.vdg
C:\nrnmodels\Cai\ca.A
C:\nrnmodels\Cai\ca.B
C:\nrnmodels\Cai\Na.vdg
C:\nrnmodels\Cai\Na.A
C:\nrnmodels\Cai\Na.B
C:\nrnmodels\Cai\leak.vdg
C:\nrnmodels\Cai\Ca.ion
C:\nrnmodels\Cai\Ca2Ikca.fBR
C:\nrnmodels\Cai\axona.neu
C:\nrnmodels\Cai\xaleak.vdg
C:\nrnmodels\Cai\axonb.neu
C:\nrnmodels\Cai\xbIkca.vdg
C:\nrnmodels\Cai\xbcat.vdg
C:\nrnmodels\Cai\xbIr.vdg
C:\nrnmodels\Cai\xbIa.vdg
C:\nrnmodels\Cai\xbDr.vdg
C:\nrnmodels\Cai\xbca.vdg
C:\nrnmodels\Cai\xbleak.vdg
C:\nrnmodels\Cai\xbNa.vdg
C:\nrnmodels\Cai\xbCa.ion
C:\nrnmodels\Cai\xbCa2Ikca.fBR
C:\nrnmodels\Cai\axonc.neu
C:\nrnmodels\Cai\xcIkca.vdg
C:\nrnmodels\Cai\xccat.vdg
C:\nrnmodels\Cai\xcIr.vdg
C:\nrnmodels\Cai\xcIa.vdg
C:\nrnmodels\Cai\xcDr.vdg
C:\nrnmodels\Cai\xcca.vdg
C:\nrnmodels\Cai\xcleak.vdg
C:\nrnmodels\Cai\xcNa.vdg
C:\nrnmodels\Cai\xcCa.ion
C:\nrnmodels\Cai\xcCa2Ikca.fBR
C:\nrnmodels\Cai\term.neu
C:\nrnmodels\Cai\tIkca.vdg
C:\nrnmodels\Cai\tcat.vdg
C:\nrnmodels\Cai\tIr.vdg
C:\nrnmodels\Cai\tDr.vdg
C:\nrnmodels\Cai\tca.vdg
C:\nrnmodels\Cai\tleak.vdg
C:\nrnmodels\Cai\tCa.ion
C:\nrnmodels\Cai\tCa2Ikca.fBR
C:\nrnmodels\Cai\mv2soma.es
C:\nrnmodels\Cai\soma2axona.es
C:\nrnmodels\Cai\axona2axonb.es
C:\nrnmodels\Cai\axonb2axonc.es
C:\nrnmodels\Cai\axonc2term.es
C:\nrnmodels\Cai\bph.ntw
C:\nrnmodels\Cai\bph.trt0
C:\nrnmodels\Cai\bph.ous_sp