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Burst induced synaptic plasticity in Apysia sensorimotor neurons (Phares et al 2003)
 
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Model Information
Model File
Accession:
34168
The Aplysia sensorimotor synapse is a key site of plasticity for several simple forms of learning. Intracellular stimulation of sensory neurons to fire a burst of action potentials at 10 Hz for 1 sec led to significant homosynaptic depression of postsynaptic responses. During the burst, the steady-state depressed phase of the postsynaptic response, which was only 20% of the initial EPSP of the burst, still contributed to firing the motor neuron. To explore the functional contribution of transient homosynaptic depression to the response of the motor neuron, computer simulations of the sensorimotor synapse with and without depression were compared. Depression allowed the motor neuron to produce graded responses over a wide range of presynaptic input strength. Thus, synaptic depression increased the dynamic range of the sensorimotor synapse and can, in principle, have a profound effect on information processing. Please see paper for results and details.
Reference:
1 .
Phares GA, Antzoulatos EG, Baxter DA, Byrne JH (2003) Burst-induced synaptic depression and its modulation contribute to information transfer at Aplysia sensorimotor synapses: empirical and computational analyses.
J Neurosci
23
:8392-401
[
PubMed
]
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Model Information
(Click on a link to find other models with that property)
Model Type:
Realistic Network;
Brain Region(s)/Organism:
Aplysia;
Cell Type(s):
Aplysia sensory neuron;
Aplysia motor neuron;
Channel(s):
I Na,t;
I N;
I A;
I K;
I Calcium;
I A, slow;
Gap Junctions:
Receptor(s):
AMPA;
Gene(s):
Transmitter(s):
Simulation Environment:
SNNAP;
Model Concept(s):
Synaptic Plasticity;
Action Potentials;
Facilitation;
Depression;
Invertebrate;
Sensory processing;
Implementer(s):
Phares, Gregg A [gregg.a.phares at uth.tmc.edu];
Search NeuronDB
for information about:
AMPA
;
I Na,t
;
I N
;
I A
;
I K
;
I Calcium
;
I A, slow
;
/
Phares
cells
LP.neu
LP_Kv.A
*
Other models using LP_Kv.A:
Burst induced synaptic plasticity in Apysia sensorimotor neurons (Phares et al 2003)
LP_Kv.B
LP_Kv.vdg
LP_leak.vdg
LP_Na.A
LP_Na.B
LP_Na.vdg
MN.neu
MN_Ca.A
MN_Ca.B
MN_Ca.vdg
MN_Kv.A
MN_Kv.B
MN_Kv.vdg
MN_leak.vdg
MN_leak_vdg.R
*
Other models using MN_leak_vdg.R:
Burst induced synaptic plasticity in Apysia sensorimotor neurons (Phares et al 2003)
Burst induced synaptic plasticity in Apysia sensorimotor neurons (Phares et al 2003)
Burst induced synaptic plasticity in Apysia sensorimotor neurons (Phares et al 2003)
Burst induced synaptic plasticity in Apysia sensorimotor neurons (Phares et al 2003)
MN_Na.A
MN_Na.B
MN_Na.vdg
MNpass.neu
SN.neu
SN_Ca.A
SN_Ca.B
SN_Ca.vdg
SN_Ka.A
SN_Ka.B
SN_Ka.vdg
SN_Ks.A
SN_Ks.vdg
SN_Kv.A
*
Other models using SN_Kv.A:
Burst induced synaptic plasticity in Apysia sensorimotor neurons (Phares et al 2003)
SN_Kv.B
SN_Kv.vdg
SN_leak.vdg
SN_Na.A
SN_Na.B
SN_Na.vdg
vdg.R
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