Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)

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Accession:34558
It has been found that in cultured Aplysia neurons bath applications of 40 mM cafffeine evokes oscillations of the membrane potential with about a 40 mV amplitude with a frequency of 0.2 to 0.5 Hz. The most probable mechanism of these caffeine-induced oscillations is inhibition of voltage-activated outward potassium current and, as can be seen from our mathematical modeling, slowdown of inactivation of inward sodium current. It seems likely that these oscillations have a purely membrane origin. Please see paper for results and details.
Reference:
1 . Komendantov AO, Kononenko NI (2000) Caffeine-induced oscillations of the membrane potential in Aplysia Neurons. Neirofiziologiya/Neurophysiology 32:102-111
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Aplysia cultured neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Activity Patterns; Bursting; Oscillations; Action Potentials; Invertebrate;
Implementer(s): Komendantov, Alexander O [akomenda at tulane.edu]; Kononenko, Nikolai I [nik137 at lamar.colostate.edu];
Search NeuronDB for information about:  I Na,t; I K;
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Komendantov
control
Fig_6
Fig_7
xls
README.txt
L7.neu *
L7.ntw *
L7_01.ous *
L7_01.smu *
L7_01.trt *
L7_01_smu.jpg
L7_K.a *
L7_K.vdg *
L7_leak.vdg *
L7_Na.A *
L7_Na.B *
L7_Na.vdg *
                            
README_Komendantov.txt (or Readme.txt in ModelDB)

This simulation reproduces the model published
in:

Komendantov, A.O. and Kononenko, N.I.  (2000)
Caffeine-induced oscillations of the membrane 
potential in Aplysia neurons.  Neurophysiology 32:
77-84.  

The results of a simulation are illustrated in 
L7_01_smu.jpg.

Example use:

Start SNNAP (double click on the SNNAP.jar file)
click on "Run Simulation"
Then in the new window "File"->"Load Simulation"
browse to and load L7_01.smu file to load a simulation
that creates a figure similar to the L7 neuron in Fig 8 
from the paper and click "Start"
See http://snnap.uth.tmc.edu/ to download SNNAP