Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)

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Accession:34558
It has been found that in cultured Aplysia neurons bath applications of 40 mM cafffeine evokes oscillations of the membrane potential with about a 40 mV amplitude with a frequency of 0.2 to 0.5 Hz. The most probable mechanism of these caffeine-induced oscillations is inhibition of voltage-activated outward potassium current and, as can be seen from our mathematical modeling, slowdown of inactivation of inward sodium current. It seems likely that these oscillations have a purely membrane origin. Please see paper for results and details.
Reference:
1 . Komendantov AO, Kononenko NI (2000) Caffeine-induced oscillations of the membrane potential in Aplysia Neurons. Neirofiziologiya/Neurophysiology 32:102-111
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Aplysia cultured neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Activity Patterns; Bursting; Oscillations; Action Potentials; Invertebrate;
Implementer(s): Komendantov, Alexander O [akomenda at tulane.edu]; Kononenko, Nikolai I [nik137 at lamar.colostate.edu];
Search NeuronDB for information about:  I Na,t; I K;
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Komendantov
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Fig_6
Fig_7
xls
README.txt
L7.neu *
L7.ntw *
L7_01.ous *
L7_01.smu *
L7_01.trt *
L7_01_smu.jpg
L7_K.a *
L7_K.vdg *
L7_leak.vdg *
L7_Na.A *
L7_Na.B *
L7_Na.vdg *
                            
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		>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
		>>    MODELE NAME: neu		>>
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>------------------------------->--------------------------------------->
   THRESHOLD:	0.0		> Threshold for transmitter release	>
>------------------------------->--------------------------------------->
   SPIKDUR:	0.003		> Spike duration. If equal 0 then 	>
				>	actual time when presynaptic	>
				>	neuronis above threshold will	>
				>	be measured.			>
>------------------------------->--------------------------------------->
   VMINIT:	-55.6		> Initial value of membrane potential.	>
>------------------------------->--------------------------------------->
   CM:		0.001		>  Membrane capacitance.		>
>------------------------------->--------------------------------------->


>------------------------------->------------------------------->
   CONDUCTANCES:		> 	List of Conductances	>
>------------------------------->------------------------------->
	leak			>	Name of conductance	>
	L7_leak.vdg		>	File Name		>
	green			>	Color			>
>------------------------------->------------------------------->
	Na			>	Name of conductance	>
	L7_Na.vdg		>	File Name		>
	green			>	Color			>
>------------------------------->------------------------------->
	K			>	Name of conductance	>
	L7_K.vdg		>	File Name		>
	green			>	Color			>
>------------------------------->------------------------------->
	END			>				>
>------------------------------->------------------------------->

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