Caffeine-induced electrical oscillations in Aplysia neurons (Komendantov, Kononenko 2000)

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Accession:34558
It has been found that in cultured Aplysia neurons bath applications of 40 mM cafffeine evokes oscillations of the membrane potential with about a 40 mV amplitude with a frequency of 0.2 to 0.5 Hz. The most probable mechanism of these caffeine-induced oscillations is inhibition of voltage-activated outward potassium current and, as can be seen from our mathematical modeling, slowdown of inactivation of inward sodium current. It seems likely that these oscillations have a purely membrane origin. Please see paper for results and details.
Reference:
1 . Komendantov AO, Kononenko NI (2000) Caffeine-induced oscillations of the membrane potential in Aplysia Neurons. Neirofiziologiya/Neurophysiology 32:102-111
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Aplysia cultured neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Activity Patterns; Bursting; Oscillations; Action Potentials; Invertebrate;
Implementer(s): Komendantov, Alexander O [akomenda at tulane.edu]; Kononenko, Nikolai I [nik137 at lamar.colostate.edu];
Search NeuronDB for information about:  I Na,t; I K;
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Komendantov
control
L7.neu *
L7.ntw *
L7_01.ous *
L7_01.trt *
L7_control.smu *
L7_K.a *
L7_K.vdg
L7_leak.vdg *
L7_Na.A *
L7_Na.B
L7_Na.vdg *
                            
>------------------------------->--------------------------------------->
  VAR_TO_GRAPH: 		>	List of current contributing	>
				>		to ion pools		>
>------------------------------->--------------------------------------->
	GRPH_CHNL:		>	Graph channel			>
>------------------------------->--------------------------------------->
	1			>	GAIN of Channel			>
	time<{ivr}            	>	Var Name for X-axis		>
		5           	>	Number of Tic Marks		>
		00.0         	>	Min Value of X			>
		20.0        	>	Max Value of X			>
		white        	>	Color of Range			>
	V[L7....]<{ivr}    	>	Var Name for Y-axis		>
		9           	>	Number of Tic Marks		>
		-70.0       	>	Min Value of Y			>
		20.0        	>	Max Value of Y			>
		white         	>	Color of RAnge			>
>------------------------------->--------------------------------------->
	END:			>					>
>------------------------------->--------------------------------------->

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