I A in Kenyon cells resemble Shaker currents (Pelz et al 1999)

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Accession:34560
Cultured Kenyon cells from the mushroom body of the honeybee, Apis mellifera, show a voltage-gated, fast transient K1 current that is sensitive to 4-aminopyridine, an A current. The kinetic properties of this A current and its modulation by extracellular K1 ions were investigated in vitro with the whole cell patch-clamp technique. The A current was isolated from other voltage-gated currents either pharmacologically or with suitable voltage-clamp protocols. Hodgkin- and Huxley-style mathematical equations were used for the description of this current and for the simulation of action potentials in a Kenyon cell model. The data of the A current were incorporated into a reduced computational model of the voltage-gated currents of Kenyon cells. In addition, the model contained a delayed rectifier K current, a Na current, and a leakage current. The model reproduces several experimental features and makes predictions. See paper for details and results.
Reference:
1 . Pelz C, Jander J, Rosenboom H, Hammer M, Menzel R (1999) IA in Kenyon cells of the mushroom body of honeybees resembles shaker currents: kinetics, modulation by K+, and simulation. J Neurophysiol 81:1749-59 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Honeybee kenyon cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Ion Channel Kinetics; Parameter Fitting; Action Potentials; Invertebrate;
Implementer(s): Baxter, Douglas;
Search NeuronDB for information about:  I Na,t; I A; I K;
 
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