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I A in Kenyon cells resemble Shaker currents (Pelz et al 1999)
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Cultured Kenyon cells from the mushroom body of the honeybee, Apis mellifera, show a voltage-gated, fast transient K1 current that is sensitive to 4-aminopyridine, an A current. The kinetic properties of this A current and its modulation by extracellular K1 ions were investigated in vitro with the whole cell patch-clamp technique. The A current was isolated from other voltage-gated currents either pharmacologically or with suitable voltage-clamp protocols. Hodgkin- and Huxley-style mathematical equations were used for the description of this current and for the simulation of action potentials in a Kenyon cell model. The data of the A current were incorporated into a reduced computational model of the voltage-gated currents of Kenyon cells. In addition, the model contained a delayed rectifier K current, a Na current, and a leakage current. The model reproduces several experimental features and makes predictions. See paper for details and results.
Pelz C, Jander J, Rosenboom H, Hammer M, Menzel R (1999) IA in Kenyon cells of the mushroom body of honeybees resembles shaker currents: kinetics, modulation by K+, and simulation.
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Neuron or other electrically excitable cell;
Honeybee kenyon cell;
Ion Channel Kinetics;
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