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I A in Kenyon cells resemble Shaker currents (Pelz et al 1999)
 
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Model Information
Model File
Accession:
34560
Cultured Kenyon cells from the mushroom body of the honeybee, Apis mellifera, show a voltage-gated, fast transient K1 current that is sensitive to 4-aminopyridine, an A current. The kinetic properties of this A current and its modulation by extracellular K1 ions were investigated in vitro with the whole cell patch-clamp technique. The A current was isolated from other voltage-gated currents either pharmacologically or with suitable voltage-clamp protocols. Hodgkin- and Huxley-style mathematical equations were used for the description of this current and for the simulation of action potentials in a Kenyon cell model. The data of the A current were incorporated into a reduced computational model of the voltage-gated currents of Kenyon cells. In addition, the model contained a delayed rectifier K current, a Na current, and a leakage current. The model reproduces several experimental features and makes predictions. See paper for details and results.
Reference:
1 .
Pelz C, Jander J, Rosenboom H, Hammer M, Menzel R (1999) IA in Kenyon cells of the mushroom body of honeybees resembles shaker currents: kinetics, modulation by K+, and simulation.
J Neurophysiol
81
:1749-59
[
PubMed
]
Citations
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Model Information
(Click on a link to find other models with that property)
Model Type:
Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Honeybee kenyon cell;
Channel(s):
I Na,t;
I A;
I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:
SNNAP;
Model Concept(s):
Ion Channel Kinetics;
Parameter Fitting;
Action Potentials;
Invertebrate;
Implementer(s):
Baxter, Douglas;
Search NeuronDB
for information about:
I Na,t
;
I A
;
I K
;
/
Pelz
README.txt
.batch
Fig12Model.jpg
Ka.A
Ka.B
Ka.vdg
Ka_VC.bch
Ka_VC.trt
Kenyon.neu
Kenyon.ntw
Kenyon_Ka_VC.ous
Kenyon_Ka_VC.smu
Kenyon_Kv_VC.ous
Kenyon_Kv_VC.smu
Kenyon_Na_VC.ous
Kenyon_Na_VC.smu
Kenyon_spk.ous
Kenyon_spk.smu
Kenyon_spk.trt
Kv.A
Kv.vdg
Kv_VC.bch
Kv_VC.trt
leak.vdg
Na.A
Na.B
Na.vdg
Na_VC.bch
Na_VC.trt
vdg_1.R
*
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