I A in Kenyon cells resemble Shaker currents (Pelz et al 1999)

 Download zip file 
Help downloading and running models
Accession:34560
Cultured Kenyon cells from the mushroom body of the honeybee, Apis mellifera, show a voltage-gated, fast transient K1 current that is sensitive to 4-aminopyridine, an A current. The kinetic properties of this A current and its modulation by extracellular K1 ions were investigated in vitro with the whole cell patch-clamp technique. The A current was isolated from other voltage-gated currents either pharmacologically or with suitable voltage-clamp protocols. Hodgkin- and Huxley-style mathematical equations were used for the description of this current and for the simulation of action potentials in a Kenyon cell model. The data of the A current were incorporated into a reduced computational model of the voltage-gated currents of Kenyon cells. In addition, the model contained a delayed rectifier K current, a Na current, and a leakage current. The model reproduces several experimental features and makes predictions. See paper for details and results.
Reference:
1 . Pelz C, Jander J, Rosenboom H, Hammer M, Menzel R (1999) IA in Kenyon cells of the mushroom body of honeybees resembles shaker currents: kinetics, modulation by K+, and simulation. J Neurophysiol 81:1749-59 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Honeybee kenyon cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Ion Channel Kinetics; Parameter Fitting; Action Potentials; Invertebrate;
Implementer(s): Baxter, Douglas;
Search NeuronDB for information about:  I Na,t; I A; I K; 
        >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
        >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
        >>   modules name: smu          >>
        >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
        >>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>


>----------------------->------------------------------->
  LOGICAL_NAME:         >       Name of Network         >
>.......................>...............................>
        Kenyon_cell     > The name of the network       >
>----------------------->------------------------------->

>----------------------->------------------------------->
  TIMING:               > Timing information in seconds >
>.......................>...............................>
        0.000000        > What value to assign to the   >
                        > variable 'time' at time=0     >
>.......................>...............................>
        0.22             > When to stop simulation (sec) >
>.......................>...............................>
        0.000001        > Step size (sec)               >
>----------------------->------------------------------->

>----------------------->------------------------------->
  ON_LINE_GRAPH:        >       On-line graph           >
>.......................>...............................>
        1               > 1 for yes, 0 for no           >
>----------------------->------------------------------->

>----------------------->------------------------------->
  STORE_RESULTS:        >       Store results           >
>.......................>...............................>
        0               > 1 for yes, 0 for no           >
>----------------------->------------------------------->

>----------------------->------------------------------->
  INT_METHOD:           >       Integration method      >
>.......................>...............................>
        1               > 1 for Euler method            >
                        > 2 for RK (under constr.)      >
                        > 3 for RKQC (under constr.)    >
>----------------------->------------------------------->

>----------------------->------------------------------->
  NETWORK:              > Structure of network          >
>.......................>...............................>
        Kenyon.ntw      > the name of the file          >
>----------------------->------------------------------->

>----------------------->------------------------------->
  OUTPUT_SETUP:         > List of variables for output  >
>.......................>...............................>
    Kenyon_Kv_VC.ous    > the name of the file          >
>----------------------->------------------------------->

>----------------------->------------------------------->
  TREATMENTS:           > External treatments           >
>.......................>...............................>
       Kv_VC.trt        > the name of the file          >
>----------------------->------------------------------->

END