I A in Kenyon cells resemble Shaker currents (Pelz et al 1999)

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Accession:34560
Cultured Kenyon cells from the mushroom body of the honeybee, Apis mellifera, show a voltage-gated, fast transient K1 current that is sensitive to 4-aminopyridine, an A current. The kinetic properties of this A current and its modulation by extracellular K1 ions were investigated in vitro with the whole cell patch-clamp technique. The A current was isolated from other voltage-gated currents either pharmacologically or with suitable voltage-clamp protocols. Hodgkin- and Huxley-style mathematical equations were used for the description of this current and for the simulation of action potentials in a Kenyon cell model. The data of the A current were incorporated into a reduced computational model of the voltage-gated currents of Kenyon cells. In addition, the model contained a delayed rectifier K current, a Na current, and a leakage current. The model reproduces several experimental features and makes predictions. See paper for details and results.
Reference:
1 . Pelz C, Jander J, Rosenboom H, Hammer M, Menzel R (1999) IA in Kenyon cells of the mushroom body of honeybees resembles shaker currents: kinetics, modulation by K+, and simulation. J Neurophysiol 81:1749-59 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Honeybee kenyon cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Ion Channel Kinetics; Parameter Fitting; Action Potentials; Invertebrate;
Implementer(s): Baxter, Douglas;
Search NeuronDB for information about:  I Na,t; I A; I K;
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>----------------------->------------------------------->
  CURNT_INJ:            > Timing for currnt injection   >
>.......................>...............................>
        A               > Name of Neuron                >
>.......................>...............................>
        0.005            >       Start injection         >
>.......................>...............................>
        0.008            >       Stop injection          >
>.......................>...............................>
        0.07            >       Magnitude               >
>     filename.fnc      >       Magnitude               >
>----------------------->------------------------------->
        END             >                               >
>----------------------->------------------------------->

>----------------------->------------------------------->
  MOD_INJ:              > Timing for injection of       >
>.......................>...............................>
>        A               > Name of Neuron                >
>.......................>...............................>
>        mod             >       Name of Modulator       >
>.......................>...............................>
>        SM              >       Name of sm              >
>.......................>...............................>
>        0.0            >       Start injection         >
>.......................>...............................>
>        0.20            >       Stop injection          >
>.......................>...............................>
>        1.00            >       Magnitude               >
>     filename.fnc      >     ? Magnitude               >
>----------------------->------------------------------->
        END             >                               >
>----------------------->------------------------------->

>----------------------->------------------------------->
  VCLAMP:               > Timing for V_clamping         >
>.......................>...............................>
>        A               > Name of Neuron                >
>.......................>...............................>
>        0.00            >       Start clamping          >
>.......................>...............................>
>        0.03            >       Stop clamping           >
>.......................>...............................>
>        -125.00          >       Magnitude               >
>     filename.fnc      >     ? Magnitude               >
>.......................>...............................>
>        A              > Name of Neuron                >
>.......................>...............................>
>        0.01            >       Start clamping          >
>.......................>...............................>
>        0.02            >       Stop clamping           >
>.......................>...............................>
>        -55.00         >       Magnitude               >
>     filename.fnc      >     ? Magnitude               >
>----------------------->------------------------------->
        END             >                               >
>----------------------->------------------------------->

>----------------------->------------------------------->
  ICLAMP:               > Timing for I_clamping         >
>.......................>...............................>
>        A               > Name of Neuron                >
>.......................>...............................>
>        Na              >       Name of Conductance     >
>.......................>...............................>
>        0.10            >       Start clamping          >
>.......................>...............................>
>        0.20            >       Stop clamping           >
>.......................>...............................>
>        1.00            >       Magnitude               >
>     filename.fnc      >     ? Magnitude               >
>----------------------->------------------------------->
        END             >                               >
>----------------------->------------------------------->
END