I A in Kenyon cells resemble Shaker currents (Pelz et al 1999)

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Accession:34560
Cultured Kenyon cells from the mushroom body of the honeybee, Apis mellifera, show a voltage-gated, fast transient K1 current that is sensitive to 4-aminopyridine, an A current. The kinetic properties of this A current and its modulation by extracellular K1 ions were investigated in vitro with the whole cell patch-clamp technique. The A current was isolated from other voltage-gated currents either pharmacologically or with suitable voltage-clamp protocols. Hodgkin- and Huxley-style mathematical equations were used for the description of this current and for the simulation of action potentials in a Kenyon cell model. The data of the A current were incorporated into a reduced computational model of the voltage-gated currents of Kenyon cells. In addition, the model contained a delayed rectifier K current, a Na current, and a leakage current. The model reproduces several experimental features and makes predictions. See paper for details and results.
Reference:
1 . Pelz C, Jander J, Rosenboom H, Hammer M, Menzel R (1999) IA in Kenyon cells of the mushroom body of honeybees resembles shaker currents: kinetics, modulation by K+, and simulation. J Neurophysiol 81:1749-59 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Honeybee kenyon cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Ion Channel Kinetics; Parameter Fitting; Action Potentials; Invertebrate;
Implementer(s): Baxter, Douglas;
Search NeuronDB for information about:  I Na,t; I A; I K;
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Ivd:		> 	Current due to a voltage-dependent conductance	>
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>------------------------------->--------------------------------------->
>				>	    _	    p			>
>	1			>	G= (g+R) x A x B 	(1)	>
>   filename.A	           >A<	>   activation function			>
>   filename.B	           >B<	>   inactivation function		>
>   filename.R	           >R<	>   random fluctuations			>
>   xxx.xx     >g uS or S/cm2<	>   use S/cm2 if using area		>
>   xxx.xx 		   >P<	>					>
>   xxx.xx 		>E mV<	>   Ivd = G x (V -E) x fBR		>
>				>   (fBr is modulation function)	>
>------------------------------->--------------------------------------->
>				>	      _	      p			>
>	2			>	Ivd= (g+R) x m x h 	(2)	>
>   filename.m		  >m<	>   HH activation function		>
>   filename.h		  >h<	>   HH inactivation function		>
>   filename.R		  >R<	>   random fluctuations			>
>   xxx.xx    >g uS or S/cm2<	>   use S/cm2 if using area		>
>   xxx.xx 		  >P<	>					>
>   xxx.xx 	       >E mV<	>   Ivd = G x (V -E) x fBr		>
>				>   (fBr is modulation function)	>
>------------------------------->--------------------------------------->
>				>	    _	    p			>
	3			>	G= (g+R) x A		(3)	>
   Kv.A		         >A<	>   activation function			>
   vdg_1.R		 >R<	>   random fluctuations			>
   0.0075     >g uS or S/cm2<	>   use S/cm2 if using area		>
   4.0 		         >P<	>					>
   -85.0 	      >E mV<	>   Ivd = G x (V -E) x fBr		>
>				>   (fBr is modulation function)	>
>------------------------------->--------------------------------------->
>				>	      _	      p			>
>	4			>	Ivd= (g+R) x m 		(4)	>
>   filename.m		  >m<	>   HH activation function		>
>   filename.R		  >R<	>   random fluctuations			>
>   xxx.xx    >g uS or S/cm2<	>   use S/cm2 if using area		>
>   xxx.xx 		  >P<	>					>
>   xxx.xx 	       >E mV<	>   Ivd = G x (V -E) x fBr		>
>				>   (fBr is modulation function)	>
>------------------------------->--------------------------------------->
>				>					>
>	5			>   Ivd = (G+R) x (V -E) x fBr	(5)	>
>   filename.R		 >R<	>   random fluctuations			>
>   xxx.xx   >g uS or S/cm2<	>   use S/cm2 if using area		>
>   xxx.xx 	      >E mV<	>   (fBr is modulation function)	>
>				>					>
>------------------------------->--------------------------------------->

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