Thalamic Relay Neuron: I-h (McCormick, Pape 1990)

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Accession:3684
NEURON mod files for the Ih current from the paper: McCormick DA, Pape HC. Properties of a hyperpolarization-activated cation current and its role in rhythmic oscillation in thalamic relay neurones. J. Physiol. 1990 431:291-318.
Reference:
1 . McCormick DA, Pape HC (1990) Properties of a hyperpolarization-activated cation current and its role in rhythmic oscillation in thalamic relay neurones. J Physiol 431:291-318 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell;
Channel(s): I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; I h;
TITLE I-h channel for Thalamic neurons from McCormick and Pape (1990)

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)

}

PARAMETER {
	v 		(mV)
        eh  		(mV)        
	celsius 	(degC)
	ghbar=.00005 	(mho/cm2)
        vhalft=-80   	(mV)
        a0t=0.0005      	(/ms)
        zetat=0.2    	(1)
        gmt=.65   	(1)
	q10=4.5
}


NEURON {
	SUFFIX htc
	NONSPECIFIC_CURRENT i
        RANGE ghbar, eh
        GLOBAL linf,taul
}

STATE {
        l
}

ASSIGNED {
	i (mA/cm2)
        linf      
        taul
}

INITIAL {
	rate(v)
	l=linf
}


BREAKPOINT {
	SOLVE states METHOD cnexp
	i = ghbar*l*(v-eh)

}


FUNCTION alpt(v(mV)) {
  alpt = exp(zetat*(v-vhalft)) 
}

FUNCTION bett(v(mV)) {
  bett = exp(zetat*gmt*(v-vhalft)) 
}

DERIVATIVE states {     : exact when v held constant; integrates over dt step
        rate(v)
        l' =  (linf - l)/taul
}

PROCEDURE rate(v (mV)) { :callable from hoc
        LOCAL qt
        qt=q10^((celsius-36)/10)
        linf = 1/(1+ exp((v+75)/5.5))
        taul = bett(v)/(qt*a0t*(1+alpt(v)))
}