Olfactory Mitral cell: AP initiation modes (Chen et al 2002)

 Download zip file   Auto-launch 
Help downloading and running models
The mitral cell primary dendrite plays an important role in transmitting distal olfactory nerve input from olfactory glomerulus to the soma-axon initial segment. To understand how dendritic active properties are involved in this transmission, we have combined dual soma and dendritic patch recordings with computational modeling to analyze action-potential initiation and propagation in the primary dendrite.
1 . Chen WR, Shen GY, Shepherd GM, Hines ML, Midtgaard J (2002) Multiple modes of action potential initiation and propagation in mitral cell primary dendrite. J Neurophysiol 88:2755-64 [PubMed]
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Olfactory bulb main mitral GLU cell; Myelinated neuron;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA;
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Synaptic Integration; Olfaction;
Implementer(s): Hines, Michael [Michael.Hines at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral GLU cell; AMPA; I Na,t; I K;

objref nil, tobj, se, pe, pestim, sestim // for restart after istimfit.hoc
strdef tstr

xpanel("Figures for Chen et. al, 2002")
xradiobutton("3a", "restart(\"fig3a\")")
xradiobutton("3b", "restart(\"fig3b\")")
xradiobutton("5a", "restart(\"fig5a\")")
xradiobutton("5b", "restart(\"fig5b\")")
xradiobutton("6", "restart(\"fig6\")")
xradiobutton("Shen99 fit", "restart(\"istimfit\")")

pwmcnt = PWManager[0].count // the initial gui should not be dismissed

proc restart() {local i
	objref se, pe, pestim, sestim
	objref graphItem, save_window_
	for i=0, n_graph_lists-1 {
	for (i= PWManager[0].count-1; i >= pwmcnt; i -= 1) {
	// under gview of MultipleRunFitter, the RegionFitness not garbage collected
	// we can't fix that here but we can destroy the Graphs so that fig5a
	// will work when it tries to "Keep Lines" for Graph[0]
	tobj = new List("RegionFitness")
	for i=0, tobj.count-1 { // really should be unreffing RegionFitness
		tobj.object(i).g = nil
	tobj = nil
	stoprun = 0
	dt = .025
	steps_per_ms = 40
	tstop = 80
	load_file(1, "param.hoc")
	sprint(tstr, "%s.hoc", $s1)
	load_file(1, tstr)