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Synaptic plasticity: pyramid->pyr and pyr->interneuron (Tsodyks et al 1998)
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Accession:
3815
An implementation of a model of short-term synaptic plasticity with NEURON. The model was originally described by Tsodyks et al., who assumed that the synapse acted as a current source, but this implementation treats it as a conductance change. Tsodyks, M., Pawelzik, K., Markram, H. Neural networks with dynamic synapses. Neural Computation 10:821-835, 1998. Tsodyks, M., Uziel, A., Markram, H. Synchrony generation in recurrent networks with frequency-dependent synapses. J. Neurosci. 2000 RC50.
Reference:
1 .
Tsodyks M, Pawelzik K, Markram H (1998) Neural networks with dynamic synapses.
Neural Comput
10
:821-35
[
PubMed
]
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Model Information
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Model Type:
Synapse;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
AMPA;
Gene(s):
Transmitter(s):
Glutamate;
Simulation Environment:
NEURON;
Model Concept(s):
Short-term Synaptic Plasticity;
Facilitation;
Depression;
Implementer(s):
Carnevale, Ted [Ted.Carnevale at Yale.edu];
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for information about:
AMPA
;
Glutamate
;
/
tsodyks
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Fig. 1A pyramid-->pyramid (depression)
Fig. 1B pyramid-->interneuron at 20 Hz (facilitation)
Fig. 1C pyramid-->interneuron at 70 Hz (facilitation-depression)