Pyramidal Neuron: Deep, Thalamic Relay and Reticular, Interneuron (Destexhe et al 1998, 2001)

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Accession:3817
This package shows single-compartment models of different classes of cortical neurons, such as the "regular-spiking", "fast-spiking" and "bursting" (LTS) neurons. The mechanisms included are the Na+ and K+ currents for generating action potentials (INa, IKd), the T-type calcium current (ICaT), and a slow voltage-dependent K+ current (IM). See http://cns.fmed.ulaval.ca/alain_demos.html
Reference:
1 . Destexhe A, Contreras D, Steriade M (1998) Mechanisms underlying the synchronizing action of corticothalamic feedback through inhibition of thalamic relay cells. J Neurophysiol 79:999-1016 [PubMed]
2 . Destexhe A, Contreras D, Steriade M (2001) LTS cells in cerebral cortex and their role in generating spike-and-wave oscillations. Neurocomputing 38:555-563
3 . Destexhe A, Sejnowski TJ (2001) Thalamocortical Assemblies-How Ion Channels, Single Neurons and large-Scale Networks Organize Sleep
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; Neocortex L5/6 pyramidal GLU cell; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron;
Channel(s): I Na,t; I T low threshold; I K; I M; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Bursting; Action Potentials; Calcium dynamics;
Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; Neocortex L5/6 pyramidal GLU cell; GabaA; GabaB; AMPA; Gaba; I Na,t; I T low threshold; I K; I M; I Sodium; I Calcium; I Potassium;
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cortex
README *
cadecay.mod *
hh2.mod *
IM.mod *
IT.mod *
demo_IN_FS.oc *
demo_PY_LTS.oc *
demo_PY_RS.oc *
mosinit.hoc *
rundemo.hoc *
sIN_template
sPY_template
sPYr_template
                            
/*--------------------------------------------------------------
	TEMPLATE FILE FOR DEFINING CORTICAL PYRAMIDAL CELLS
	---------------------------------------------------

	SIMPLIFIED NEURONS:

	- one compartment model and currents derived from:

 	McCormick, D.A., Wang, Z. and Huguenard, J. Neurotransmitter 
	control of neocortical neuronal activity and excitability. 
	Cerebral Cortex 3: 387-398, 1993.

	- passive
	- HH: Traub
	- IM: m format

	Alain Destexhe, Laval University, 1995

--------------------------------------------------------------*/


print " "
print " << defining template for one-compartment sPY cell >> "
print " "


begintemplate sPY		// create a new template object
public soma

create soma[1]

proc init() { local v_potassium, v_sodium

  v_potassium = -100		// potassium reversal potential 
  v_sodium = 50			// sodium reversal potential 

  soma {
	Ra = 100		// geometry 
	nseg = 1
	diam = 96
	L = 96			// so that area is about 29000 um2
	cm = 1

	insert pas		// leak current 
	e_pas = -70
	g_pas = 0.0001		// Rin = 34 Meg

	// conversion with McC units: 
	// g(S/cm2) = g(nS)*1e-9/29000e-8
	//	    = g(nS) * 3.45e-6

	insert hh2		// Hodgin-Huxley INa and IK 
	ek = v_potassium
	ena = v_sodium
	vtraub_hh2 = -55	// Resting Vm, BJ was -55
	gnabar_hh2 = 0.05	// McCormick=15 muS, thal was 0.09
	gkbar_hh2 = 0.005	// spike duration of pyr cells


	insert im		// M current 
	taumax_im = 1000
	gkbar_im = 7e-5		// Diego's IM (copyrighted)

//	insert iahp
//	alpha_iahp = 1.25e9
//	beta_iahp = 0.001
//	gkbar_iahp = 1.7e-5	// McCormick=5 nS

//	insert cad		// calcium decay
//	depth_cad = 1		// McCormick= 0.1 um
//	taur_cad = 5		// McCormick=1 ms !!!
//	cainf_cad = 2.4e-4	// McCormick=0
//	kt_cad = 0		// no pump
  }

  print " "
  print "<< sPY: passive, INa, IK, IM inserted >>"
  print " "

}
endtemplate sPY