Kenyon cells in the honeybee (Wustenberg et al 2004)

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Accession:42022
The mushroom body of the insect brain is an important locus for olfactory information processing and associative learning. ... Current- and voltage-clamp analyses were performed on cultured Kenyon cells from honeybees. ... Voltage-clamp analyses characterized a fast transient Na+ current (INa), a delayed rectifier K+ current (IK,V) and a fast transient K+ current (IK,A). Using the neurosimulator SNNAP, a Hodgkin-Huxley type model was developed and used to investigate the roles of the different currents during spiking. The model led to the prediction of a slow transient outward current (IK,ST) that was subsequently identified by reevaluating the voltage-clamp data. Simulations indicated that the primary currents that underlie spiking are INa and IK,V, whereas IK,A and IK,ST primarily determined the responsiveness of the model to stimuli such constant or oscillatory injections of current. See paper for more details.
Reference:
1 . W├╝stenberg DG, Boytcheva M, Gr├╝newald B, Byrne JH, Menzel R, Baxter DA (2004) Current- and voltage-clamp recordings and computer simulations of Kenyon cells in the honeybee. J Neurophysiol 92:2589-603 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Honeybee kenyon cell;
Channel(s): I A; I K; I K,leak; I Sodium; I A, slow;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: SNNAP;
Model Concept(s): Action Potentials; Invertebrate; Olfaction;
Implementer(s): Baxter, Douglas; Boytcheva, Milena [milena at cs.tu-berlin.de]; Wustenberg, Daniel [Daniel.Wustenberg at uth.tmc.edu];
Search NeuronDB for information about:  I A; I K; I K,leak; I Sodium; I A, slow;
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>----------------------->------------------------------->
  LOGICAL_NAME:         >       Name of Network         >
>.......................>...............................>
        HHKenyon     	> The name of the network       >
>----------------------->------------------------------->

>----------------------->------------------------------->
  TIMING:               > Timing information in seconds >
>.......................>...............................>
        0.0000000000    > What value to assign to the   >
                        > variable 'time' at time=0     >
>.......................>...............................>
        1.0000000000    > When to stop the simulation   >
>.......................>...............................>
        0.0000050000    > Step size (h)                 >
>----------------------->------------------------------->

>----------------------->------------------------------->
  ON_LINE_GRAPH:        >       On-line graph           >
>.......................>...............................>
        1               > 1 for yes, 0 for no           >
>----------------------->------------------------------->

>----------------------->------------------------------->
  STORE_RESULTS:        >       Store results           >
>.......................>...............................>
        0               > 1 for yes, 0 for no           >
>----------------------->------------------------------->

>----------------------->------------------------------->
  INT_METHOD:           >       Integration method      >
>.......................>...............................>
        1               > 1 for Euler method            >
                        > 2 for RK                      >
                        > 3 for RKQC                    >
>----------------------->------------------------------->

>----------------------->------------------------------->
  NETWORK:              > Structure of network          >
>.......................>...............................>
        HHKenyon.ntw    > the name of the file          >
>----------------------->------------------------------->

>----------------------->------------------------------->
  OUTPUT_SETUP:         > List of variables for output  >
>.......................>...............................>
        HHKenyon.ous      > the name of the file          >
>----------------------->------------------------------->

>----------------------->------------------------------->
  TREATMENTS:           > External treatments           >
>.......................>...............................>
        HHKenyon.trt      > the name of the file          >
>----------------------->------------------------------->
  INT_&_FIRE:           >       Integration method      >
>.......................>...............................>
        0.0020000000    > Integrate And Fire step_size  >
>----------------------->------------------------------->

END