NEURON mod files from the paper:
Sonia Gasparini, Michele Migliore, and Jeffrey C. Magee
On the initiation and propagation of dendritic spikes in CA1 pyramidal neurons,
J.Neurosci. 24:11046-11056 (2004).
The paper investigates the dendritic spike probability as a function
of the number of activated synaptic input and their spatial and temporal distribution.
The results suggest that highly synchronized and moderately clustered inputs
have the highest probability to generate a dendritic spike.
The main effect is demonstrated here by reproducing the simulations
in Fig.5A of the paper, in which 5 synapses were activated
in the same compartment with different time delays.
Simulations can be run for different kind of synaptic input:
- current pulses
Under unix systems:
to compile the mod files use the command
and run the simulation hoc file with the command
Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
will open the simulation window.
Questions on how to use this model
should be directed to email@example.com