Bursting and resonance in cerebellar granule cells (D'Angelo et al. 2001)

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Accession:46839
In this study we report theta-frequency (3-12 Hz) bursting and resonance in rat cerebellar granule cells and show that these neurons express a previously unidentified slow repolarizing K1 current (IK-slow ). Our experimental and modeling results indicate that IK-slow was necessary for both bursting and resonance. See paper for more.
Reference:
1 . D'Angelo E, Nieus T, Maffei A, Armano S, Rossi P, Taglietti V, Fontana A, Naldi G (2001) Theta-frequency bursting and resonance in cerebellar granule cells: experimental evidence and modeling of a slow k+-dependent mechanism. J Neurosci 21:759-70 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum interneuron granule GLU cell;
Channel(s): I A; I K; I h; I Calcium; I A, slow;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Ion Channel Kinetics; Oscillations;
Implementer(s): D'Angelo, Egidio [dangelo at unipv.it];
Search NeuronDB for information about:  Cerebellum interneuron granule GLU cell; I A; I K; I h; I Calcium; I A, slow;
TITLE Electrode for sinusoidal current clamping

COMMENT
	Author: A. Fontana
	Last revised: 28.3.99
ENDCOMMENT

NEURON {
	POINT_PROCESS GrC_Sine
	RANGE del, dur, amp, i, freq, phase
	ELECTRODE_CURRENT i
}
UNITS {
	(nA) = (nanoamp)
}

PARAMETER {
	PI = 3.141592
	del (ms)
	dur (ms)	
	amp = 0.006 (nA)
	freq = 4 (1/ms)
	phase = 0
}
ASSIGNED { i (nA) }

INITIAL {
	i = 0
}

BREAKPOINT {
	at_time(del)
	at_time(del+dur)

	if (t < del + dur && t > del) {

		
		i = amp*sin(2*PI*freq*t/1000)


	}else{
		i = 0
	}
}