Bursting and resonance in cerebellar granule cells (D'Angelo et al. 2001)

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Accession:46839
In this study we report theta-frequency (3-12 Hz) bursting and resonance in rat cerebellar granule cells and show that these neurons express a previously unidentified slow repolarizing K1 current (IK-slow ). Our experimental and modeling results indicate that IK-slow was necessary for both bursting and resonance. See paper for more.
Reference:
1 . D'Angelo E, Nieus T, Maffei A, Armano S, Rossi P, Taglietti V, Fontana A, Naldi G (2001) Theta-frequency bursting and resonance in cerebellar granule cells: experimental evidence and modeling of a slow k+-dependent mechanism. J Neurosci 21:759-70 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum interneuron granule GLU cell;
Channel(s): I A; I K; I h; I Calcium; I A, slow;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Ion Channel Kinetics; Oscillations;
Implementer(s): D'Angelo, Egidio [dangelo at unipv.it];
Search NeuronDB for information about:  Cerebellum interneuron granule GLU cell; I A; I K; I h; I Calcium; I A, slow;
// Cerebellum Granular Cell Model
// Last revised by Fontana Andrea 5.2.1999 
// Last revised by Nieus Thierry 11.1.2001 


xopen("$(NEURONHOME)/lib/hoc/noload.hoc") 

/*
 General settings
*/ 
v_init = -80
tstop = 1000 //for IClamp
//tstop = 50 //for VClamp
dt = 0.025
secondorder=0
celsius = 30 
SogliaSpike=0


/*
 Single compartment cell
*/
create soma 
soma { 
	nseg = 1 
	diam = 9.76 
	L = 9.76 
	cm = 1
	Ra = 100
} 

Area = PI*soma.diam*soma.L*1e-8

access soma

insert GrC_Lkg1
insert GrG_Na
insert GrG_Nar
insert GrG_KV 
insert GrC_KA 
insert GrC_Kir 
insert GrC_KCa
insert GrC_CaHVA 
insert Calc
insert GrC_pNa
insert GrG_KM
insert GrC_Lkg2

usetable_GrG_Na = 0
usetable_GrC_pNa = 0
usetable_GrC_CaHVA = 0
usetable_GrG_KV = 0
usetable_GrC_KA = 0
usetable_GrC_Kir = 0
usetable_GrC_KCa = 0
usetable_GrG_KM = 0

ena = 87.39
ek = -84.69
eca = 129.33
ecl = -65

/*
 Current clamps
*/

objectvar stim0, stim


/*
Sinusoidal Pulse
*/
objectvar sinu




/*
 Start GUI
*/
load_proc("nrnmainmenu") 
nrnmainmenu() 
xopen("grc_xpa1.hoc")

/*
 Initialization
*/
finitialize(v_init)

// Current clamp
/*
 Procedures to record data in files...
*/
objref tvec, data, file, vettintegra, vettore
tvec = new Vector()
data = new Vector()
tvec.record(&t)
data.record(&soma.v(0.5),tvec)